4-(3-Fluoropyridin-2-yl)-1-methylpiperidin-4-ol | 90606-76-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(3-Fluoropyridin-2-yl)-1-methylpiperidin-4-ol
• CAS: 90606-76-1
• 化学式: C₁₁H₁₅FN₂O
• 分子量: 210.251
• InChiKey: HLAXAWSSBXUZCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  36.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(3-Fluoropyridin-2-yl)-1-methylpiperidin-4-ol 在 氯化亚砜 作用下， 反应 3.0h， 以0.75%的产率得到1-methyl-4-(3-fluoro-2-pyridinyl)-1,2,5,6-tetrahydropyridine
  参考文献：
  名称：

  Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines

  摘要：

  A series of pyridinyltetrahydropyridine derivatives was synthesized and evaluated as adrenoceptor and tetrabenazine antagonists. 4-(3-Fluoro-2-pyridinyl)-1,2,5,6-tetrahydropyridine proved to be the most potent and selective alpha 2-adrenoceptor antagonist of the series as measured in vitro by displacement of [3H]clonidine and [3H]prazosin from membrane binding sites of calf cerebral cortex and by antagonism of the effects of clonidine and methoxamine in the rat isolated, field-stimulated vas deferens. In addition, this compound, and the corresponding desfluoro derivative, blocked tetrabenazine-induced ptosis in the mouse.

  DOI：

  10.1021/jm00375a017
• 作为产物：
  描述：

  2-溴-3-氨基吡啶 在 盐酸 、 hexafluorophosphoric acid 、 正丁基锂 、 sodium nitrite 作用下， 反应 2.0h， 生成 4-(3-Fluoropyridin-2-yl)-1-methylpiperidin-4-ol
  参考文献：
  名称：

  Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines

  摘要：

  A series of pyridinyltetrahydropyridine derivatives was synthesized and evaluated as adrenoceptor and tetrabenazine antagonists. 4-(3-Fluoro-2-pyridinyl)-1,2,5,6-tetrahydropyridine proved to be the most potent and selective alpha 2-adrenoceptor antagonist of the series as measured in vitro by displacement of [3H]clonidine and [3H]prazosin from membrane binding sites of calf cerebral cortex and by antagonism of the effects of clonidine and methoxamine in the rat isolated, field-stimulated vas deferens. In addition, this compound, and the corresponding desfluoro derivative, blocked tetrabenazine-induced ptosis in the mouse.

  DOI：

  10.1021/jm00375a017

文献信息

• Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
  申请人：Baskaran Subramanian

  公开号：US20100204265A1

  公开（公告）日：2010-08-12

  Provided are certain chemical entities, pharmaceutical compositions, and methods of treatment of a member of the flaviviradae family of viruses such as hepacivirus (Hepatitis C or HCV).

  提供了一些化学实体、药物组合物以及治疗黄病毒科家族成员，如肝病毒（丙型肝炎或HCV）的方法。
• Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines
  作者：Walfred S. Saari、Wasyl Halczenko、Joel R. Huff、James P. Guare、Cecilia A. Hunt、William C. Randall、Victor J. Lotti、George G. Yarbrough

  DOI：10.1021/jm00375a017

  日期：1984.9

  A series of pyridinyltetrahydropyridine derivatives was synthesized and evaluated as adrenoceptor and tetrabenazine antagonists. 4-(3-Fluoro-2-pyridinyl)-1,2,5,6-tetrahydropyridine proved to be the most potent and selective alpha 2-adrenoceptor antagonist of the series as measured in vitro by displacement of [3H]clonidine and [3H]prazosin from membrane binding sites of calf cerebral cortex and by antagonism of the effects of clonidine and methoxamine in the rat isolated, field-stimulated vas deferens. In addition, this compound, and the corresponding desfluoro derivative, blocked tetrabenazine-induced ptosis in the mouse.