4-hydroxy-3-(4-phenylphenyl)naphthalene-1,2-dione | 67287-16-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-hydroxy-3-(4-phenylphenyl)naphthalene-1,2-dione
• 英文别名: 2-biphenyl-4-yl-3-hydroxy-[1,4]naphthoquinone；2-Biphenyl-4-yl-3-hydroxy-[1,4]naphthochinon；2-(biphenyl-4-yl)-3-hydroxy-1,4-naphthoquinone
• CAS: 67287-16-5
• 化学式: C₂₂H₁₄O₃
• 分子量: 326.351
• InChiKey: IHFLHZSBCRNHGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  25.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.37
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  1,4-萘醌 在 sodium hydroxide 、 三氟化硼乙醚 、 铜 、 溶剂黄146 作用下， 生成 4-hydroxy-3-(4-phenylphenyl)naphthalene-1,2-dione
  参考文献：
  名称：

  Fieser et al., Journal of the American Chemical Society, 1948, vol. 70, p. 3177

  摘要：

  DOI：

文献信息

• SHCHERBAN A. I.; ALEKSYUK M. P.; XARITONOV G. V., IZV. VUZOV. XIMIYA I XIM. TEXNOL.,
  作者：SHCHERBAN A. I.、 ALEKSYUK M. P.、 XARITONOV G. V.

  DOI：——

  日期：——
• ANTIMICROBIAL COMPOUNDS OF 1,4-NAPHTOQUINONE STRUCTURE
  申请人：Boum, II Yap Jean-Bertrand

  公开号：US20130102650A1

  公开（公告）日：2013-04-25

  The present invention relates to a compound having formula (I) wherein: R 1 is chosen from the group consisting of: phenyl group, possibly substituted, —CH 2 —C 6 H 4 —R′ 1 group, R′ 1 being chosen from the group consisting of: H, —OH, halogen, alkyl, aryl, CHO, —CN, —NO 2 , —SR α , —OR α , —NR α R β , —CONR α R β , —COOR α , and —NHCOR α , R α and R β representing independently from each other H, an alkyl group or an aryl group, R′ 1 being preferably in para position, and —CH 2 —CO—R′ group, R′ representing an aryl or heteroaryl group, said aryl and heteroaryl groups being possibly substituted, R 2 is chosen from the group consisting of: —OH and halogen, and R 3 , R 4 , R 5 and R 6 are in particular H, for its use for the prevention and/or the treatment of bacterial infections.
• [EN] ANTIMICROBIAL COMPOUNDS OF 1,4- NAPHTOQUINONE STRUCTURE<br/>[FR] COMPOSÉS ANTIMICROBIENS À STRUCTURE 1,4-NAPHTOQUINONE
  申请人：INST NAT SANTE RECH MED

  公开号：WO2011124697A1

  公开（公告）日：2011-10-13

  The present invention relates to a compound having formula (I) wherein: R1 is chosen from the group consisting of: phenyl group, possibly substituted, -CH2-C6H4-R'1 group, R'1 being chosen from the group consisting of: H, -OH, halogen, alkyl, aryl, CHO, -CN, -NO2, -SRα, -ORα, - NRαRβ, -CONRαRβ, -COORα, and -NHCORα, Rα and Rβ representing independently from each other H, an alkyl group or an aryl group, R'1 being preferably in para position, and -CH2-CO-R' group, R' representing an aryl or heteroaryl group, said aryl and heteroaryl groups being possibly substituted, R2 is chosen from the group consisting of: -OH and halogen, and R3, R4, R5 and R6 are in particular H, for its use for the prevention and/or the treatment of bacterial infections.
• Fieser et al., Journal of the American Chemical Society, 1948, vol. 70, p. 3177
  作者：Fieser et al.

  DOI：——

  日期：——