磷酸亚精胺 | 49721-50-8

• 物质功能分类: 有机原料 - 有机膦化合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: 磷酸亚精胺
• 中文别名: 亚精胺磷酸盐；亚精胺 磷酸盐
• 英文名称: N1-(3-Aminopropyl)butane-1,4-diamine phosphate
• 英文别名: N'-(3-aminopropyl)butane-1,4-diamine;phosphoric acid
• CAS: 49721-50-8
• 化学式: C7H22N3O4P
• 分子量: 243.24
• InChiKey: LEYFIQPTQUZRIJ-UHFFFAOYSA-N

物化性质

• 熔点：
  200-210 °C (dec.)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.26
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  142
• 氢给体数：
  6
• 氢受体数：
  7

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• RTECS号：
  EJ7020000
• 海关编码：
  2922499990

制备方法与用途

制备方法

生化研究。

用途简介 用途

生化研究。

文献信息

• Human telomerase catalytic subunit
  申请人：Geron Corporation

  公开号：EP0841396A1

  公开（公告）日：1998-05-13

  The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.

  本发明提供了与人类端粒酶的催化蛋白亚基--人类端粒酶逆转录酶（hTRT）有关的组合物和方法。本发明的多核苷酸和多肽可用于人类疾病的诊断、预后和治疗，改变细胞和生物体的增殖能力，以及鉴定和筛选用于治疗癌症等疾病的化合物和疗法。
• Novel telomerase
  申请人：——

  公开号：US20020164786A1

  公开（公告）日：2002-11-07

  The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subunits of Euplotes aediculatus , and related sequences from Schizosaccharomyces, Saccharomyces sequences, and human telomerase. The present invention is also directed to polypeptides comprising these telomerase protein subunits, as well as functional polypeptides and ribonucleoproteins that contain these subunits.

  本发明涉及新型端粒酶核酸和氨基酸。特别是，本发明涉及编码各种端粒酶蛋白亚基和基序的核酸和氨基酸序列，包括123 kDa和43 kDa端粒酶蛋白亚基的 的 123 kDa 和 43 kDa 端粒酶蛋白亚基 以及来自裂殖酵母、酵母序列和人类端粒酶的相关序列。本发明还涉及包含这些端粒酶蛋白亚基的多肽，以及包含这些亚基的功能性多肽和核糖核蛋白。
• NOVEL TELOMERASE
  申请人：——

  公开号：US20030009019A1

  公开（公告）日：2003-01-09

  The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subunits of Euplotes aediculatus , and related sequences from Schizosaccharomyces, Saccharomyces sequences, and human telomerase. The present invention is also directed to polypeptides comprising these telomerase protein subunits, as well as functional polypeptides and ribonucleoproteins that contain these subunits.

  本发明涉及新型端粒酶核酸和氨基酸。特别是，本发明涉及编码各种端粒酶蛋白亚基和基序的核酸和氨基酸序列，包括123 kDa和43 kDa端粒酶蛋白亚基的 的 123 kDa 和 43 kDa 端粒酶蛋白亚基 以及来自裂殖酵母、酵母序列和人类端粒酶的相关序列。本发明还涉及包含这些端粒酶蛋白亚基的多肽，以及包含这些亚基的功能性多肽和核糖核蛋白。
• Vector encoding inactivated telomerase for treating cancer
  申请人：GERON CORPORATION

  公开号：US20040242529A1

  公开（公告）日：2004-12-02

  The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.

  本发明提供了与人类端粒酶的催化蛋白亚基--人类端粒酶逆转录酶（hTRT）有关的组合物和方法。本发明的多核苷酸和多肽可用于人类疾病的诊断、预后和治疗，改变细胞和生物体的增殖能力，以及鉴定和筛选用于治疗癌症等疾病的化合物和疗法。
• Vaccine containing the catalytic subunit of telomerase for treating cancer
  申请人：Cech R. Thomas

  公开号：US20050013825A1

  公开（公告）日：2005-01-20

  The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.

  本发明提供了与人类端粒酶的催化蛋白亚基--人类端粒酶逆转录酶（hTRT）有关的组合物和方法。本发明的多核苷酸和多肽可用于人类疾病的诊断、预后和治疗，改变细胞和生物体的增殖能力，以及鉴定和筛选用于治疗癌症等疾病的化合物和疗法。