N-propyl-1-(2-hydroxyphenyl)methanimine | 146305-09-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-propyl-1-(2-hydroxyphenyl)methanimine
• 英文别名: 2-[(E)-(n-propylimino)methyl]phenol；(E)-2-[(propylimino)methyl]phenol；2-[(E)-(propylimino)methyl]phenol；salpnH；N-Propyl-salicylaldimin
• CAS: 146305-09-1
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: FSVBAJHJVAWEID-DHZHZOJOSA-N

物化性质

• 沸点：
  269.7±23.0 °C(Predicted)
• 密度：
  0.98±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.22
• 重原子数：
  12.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  32.59
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  五羰基氯铼(I) 、 N-propyl-1-(2-hydroxyphenyl)methanimine 以 甲苯 为溶剂， 以50%的产率得到(2-[(E)-(n-propylimino)methyl]phenolato)2Re2(CO)6
  参考文献：
  名称：

  Center-symmetric dimeric Re(CO)3+ complexes with Schiff base derivatives of salicylic aldehyde

  摘要：

  A simple synthetic procedure (reaction between Re(CO)(5)Cl and 2-[(E)-(phenylimino)methyl]- or 2-[(E)-(n-propylimino)-methyl]-phenol) leads to novel dimeric Re-2(CO)(6)(N boolean AND O-)(2) complexes with the structures confirmed by means of X-ray crystallography. The obtained species have been characterized by means of elemental analysis, FT-IR, UV-VIS absorption, and EI-MS spectroscopy. The solvolysis experiments performed in dimethylsulfoxide solutions point to well pronounced stability of the investigated species. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2011.08.006
• 作为产物：
  描述：

  2-{[(E)-2-Phenylselanyl-propylimino]-methyl}-phenol 在 偶氮二异丁腈 、 三正丁基氢锡 、 sodium tetrahydroborate 作用下， 以 苯 、 甲醇 为溶剂， 生成 N-propyl-1-(2-hydroxyphenyl)methanimine
  参考文献：
  名称：

  Investigations into a free radical-mediated 1,2-imino migration

  摘要：

  The radical reactions of a series of bromides 9a-c and selenides 12-15 have been investigated to determine the factors that are important for a successful radical-mediated 1,2-imino migration. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.09.151

文献信息

• Organocatalysis of CN/CN and CC/CN Exchange in Dynamic Covalent Chemistry
  作者：Nadine Wilhelms、Sirinan Kulchat、Jean-Marie Lehn

  DOI：10.1002/hlca.201200515

  日期：2012.12

  reversibly formed CN bond plays a very important role in dynamic covalent chemistry and the CN/CN exchange of components between different imine constituents to create dynamic covalent libraries has been extensively used. To facilitate diversity generation, we have investigated an organocatalyzed approach, using L‐proline as catalyst, to accelerate the formation of dynamic libraries of [n×n] imine components

  可逆形成的CN键在动态共价化学中起着非常重要的作用，并且在不同亚胺成分之间组分的CN/ C exchangeN交换以创建动态共价文库已被广泛使用。为了促进多样性的产生，我们研究了一种有机催化方法，使用L-脯氨酸作为催化剂，以加速[ n × n ]亚胺组分动态库的形成。在某些条件下，有机催化方法也已扩展到巴比妥酸的Knoevenagel衍生物和亚胺之间的可逆CC/CN交换过程，从而增加了多样性。
• PREPARATION OF HYDROXYAROMATIC ALDEHYDES
  申请人：Maliverney Christian

  公开号：US20110306802A1

  公开（公告）日：2011-12-15

  Hydroxyaromatic aldehydes are prepared by oxidation of a corresponding mandelic derivative carried out in a basic medium and in the presence of a catalytic system containing at least two metal elements.

  羟基芳香醛是通过在碱性介质中，在至少含有两种金属元素的催化体系存在下氧化相应的苦杏仁衍生物制备的。
• The influence of RAPTA moieties on the antiproliferative activity of peripheral-functionalised poly(salicylaldiminato) metallodendrimers
  作者：Preshendren Govender、Lara C. Sudding、Catherine M. Clavel、Paul J. Dyson、Bruno Therrien、Gregory S. Smith

  DOI：10.1039/c2dt31337e

  日期：——

  Cationic N,O-chelating dendrimers functionalised on the periphery with RAPTA-like (ruthenium(II)-arene-1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane) moieties have been synthesised and characterised using NMR and IR spectroscopy, elemental analysis and MALDI-TOF/HR-ESI mass spectrometry. Metallodendrimers from the first to the fourth-generation containing up to 32 peripheral ruthenium-arene-PTA moieties were obtained. Model mononuclear analogues, [Ru(η6-p-cymene)((C7H5NO)-κ2-N,O)(PTA)}((CH2)3)][PF6] and [Ru(η6hexamethylbenzene)((C7H5NO)-κ2-N,O)(PTA)}((CH2)3)][PF6], have been prepared and their structures were determined by single crystal X-ray diffraction analysis. The cytotoxicities of the metallodendrimers and their mononuclear analogues were established on A2780 and A2780cisR human ovarian carcinoma cancer cells and model human embryonic kidney (HEK) cells.

  利用核磁共振和红外光谱、元素分析和 MALDI-TOF/HR-ESI 质谱法合成了外围具有 RAPTA 类（钌（II）-烯-1,3,5-三氮杂-7-磷杂环[3.3.1.1]癸烷）分子功能的阳离子 N，O-螯合树枝状聚合物，并对其进行了表征。获得了从第一代到第四代的金属二聚体，其中包含多达 32 个外围钌-烯-PTA 分子。制备了模型单核类似物[Ru(η6-p-cymene)((C7H5NO)-κ2-N,O)(PTA)}((CH2)3)][PF6]和[Ru(η6-hexamethylbenzene)(( )-κ2-N,O)(PTA)}(( )3)][PF6]，并通过单晶 X 射线衍射分析确定了它们的结构。在 A2780 和 A2780cisR 人类卵巢癌癌细胞以及模型人类胚胎肾（HEK）细胞上确定了金属二聚体及其单核类似物的细胞毒性。
• Luminescent bi-metallic fluoroborate derivatives of bulky salen ligands
  作者：Samuel Guieu、Francisco Cardona、João Rocha、Artur M. S. Silva

  DOI：10.1039/c4nj00941j

  日期：——

  Decorating the periphery of dimeric boranils with phenyl substituents enhanced their emission efficiency, even if the substituents are not conjugated with the boron centers.

  在二聚硼酰胺的周围装饰苯基取代基可以增强它们的发射效率，即使这些取代基与硼中心不共轭。
• Method for Producing Aromatic Compound Polymer
  申请人：Higashimura Hideyuki

  公开号：US20090018309A1

  公开（公告）日：2009-01-15

  A method for producing an aromatic compound polymer comprising oxidatively polymerizing one or more of aromatic compound(s) having two or more hydrogen atoms directly connected to aromatic ring(s), in the presence of an oxidizing agent, wherein the method employs a catalyst composed of a transition metal complex or a catalyst prepared from a transition metal complex and an activating agent, and said catalyst has a parameter P defined by the following formula (A) of 0.50 or more, and a parameter Eo defined by the following formula (B) of 0.50 [V] or more: P=Af/Ai (A) and Eo =( Epa+Epc )/2[V]  (B).

  一种生产芳香族化合物聚合物的方法，包括在氧化剂存在下氧化聚合具有两个或更多氢原子直接连接到芳香环的一个或多个芳香族化合物，其中该方法采用由过渡金属配合物或由过渡金属配合物和活化剂制备的催化剂，所述催化剂具有以下公式（A）定义的参数P，P的值为0.50或更高，并且具有以下公式（B）定义的参数Eo，Eo的值为0.50 [V]或更高：P=Af/Ai（A）和Eo=(Epa+Epc)/2[V]（B）。