1,4-diacetylpiperazine-2,3-diyl diacetate | 1534-17-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,4-diacetylpiperazine-2,3-diyl diacetate
• 英文别名: 2,3-Diacetoxy-1,4-diacetylpiperazine；(1,4-diacetyl-3-acetyloxypiperazin-2-yl) acetate
• CAS: 1534-17-4
• 化学式: C₁₂H₁₈N₂O₆
• 分子量: 286.285
• InChiKey: SMWGULOZUIMEFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  93.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,4-diacetylpiperazine-2,3-diyl diacetate 在 对甲苯磺酸 作用下， 以 乙腈 为溶剂， 以38%的产率得到1,4-diacetyl-1,4,5,6-tetrahydropyrazin-2-yl acetate
  参考文献：
  名称：

  Derivatives of 1,1,2,2-tetraaminoethane: II. Condensation of 4,5-diacetoxy-1,3-diacetylimidazolidine and 2,3-diacetoxy-1,4-diacetylpiperazine with nitrogen-containing nucleophiles

  摘要：

  Reactions of 4,5-diacetoxy-1,3-diacetylimidazolidine and 2,3-diacetoxy-1,4-diacetylpiperazine with acetamide and ethyl carbamate gave 1,3-diacetyl-4,5-bis(acetylamino)imidazolidine, 1,4-diacetyl-2,3-bis(acetylamino)piperazine, 1,3-diacetyl-4,5-bis(ethoxycarbonylamino)imidazolidine, and 1,4-diacetyl-2,3-bis(ethoxycarbonylamino)piperazine, respectively. Condensation products of 4,5-diacetoxy-1,3-diacetylimidazolidine and 2,3-diacetoxy-1,4-diacetylpiperazine with urea, furazan-3,4-diamine, and 4-phenylfurazan-3-amine were isolated.

  DOI：

  10.1134/s1070428007040185
• 作为产物：
  描述：

  N,N-二乙酰基乙二胺 在 吡啶 、 sodium carbonate 、 三乙胺 作用下， 以 水 为溶剂， 生成 1,4-diacetylpiperazine-2,3-diyl diacetate
  参考文献：
  名称：

  Derivatives of 1,1,2,2-tetraaminoethane: II. Condensation of 4,5-diacetoxy-1,3-diacetylimidazolidine and 2,3-diacetoxy-1,4-diacetylpiperazine with nitrogen-containing nucleophiles

  摘要：

  Reactions of 4,5-diacetoxy-1,3-diacetylimidazolidine and 2,3-diacetoxy-1,4-diacetylpiperazine with acetamide and ethyl carbamate gave 1,3-diacetyl-4,5-bis(acetylamino)imidazolidine, 1,4-diacetyl-2,3-bis(acetylamino)piperazine, 1,3-diacetyl-4,5-bis(ethoxycarbonylamino)imidazolidine, and 1,4-diacetyl-2,3-bis(ethoxycarbonylamino)piperazine, respectively. Condensation products of 4,5-diacetoxy-1,3-diacetylimidazolidine and 2,3-diacetoxy-1,4-diacetylpiperazine with urea, furazan-3,4-diamine, and 4-phenylfurazan-3-amine were isolated.

  DOI：

  10.1134/s1070428007040185