4-氨基-5-(2-氨基乙基)苯-1,2-二醇 | 38411-80-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 4-氨基-5-(2-氨基乙基)苯-1,2-二醇
• 英文名称: 6-Amino-dopamin
• 英文别名: 6-Aminodopamine；4-amino-5-(2-aminoethyl)benzene-1,2-diol
• CAS: 38411-80-2
• 化学式: C₈H₁₂N₂O₂
• 分子量: 168.195
• InChiKey: JOMLIKNXFZFNRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  92.5
• 氢给体数：
  4
• 氢受体数：
  4

安全信息

• 海关编码：
  2922299090

反应信息

• 作为反应物：
  描述：

  4-氨基-5-(2-氨基乙基)苯-1,2-二醇 在 水 、 碳酸氢钠 作用下， 生成 5,6-二羟基吲哚
  参考文献：
  名称：

  42.黑色素及其前体。第六部分 5：6-二羟基吲哚及其衍生物的进一步合成

  摘要：

  DOI：

  10.1039/jr9530000200

文献信息

• CONJUGATED ANTI-MICROBIAL COMPOUNDS AND CONJUGATED ANTI-CANCER COMPOUNDS AND USES THEREOF
  申请人：PONO CORPORATION

  公开号：US20150150995A1

  公开（公告）日：2015-06-04

  Disclosed herein are synthesis methods for generation of conjugated anti-microbial compounds and conjugated anti-cancer compounds. Several embodiments, related to the uses of such compounds in the treatment of infections, in particular those caused by drug-resistant bacteria. Some embodiments relate to targeting cancer based on the metabolic signature of tumor cells.

  本文公开了合成共轭抗微生物化合物和共轭抗癌化合物的方法。其中几种实施例与上述化合物在治疗感染方面的应用有关，特别是那些由耐药细菌引起的感染。一些实施例涉及基于肿瘤细胞代谢特征的癌症治疗。
• Method for the production of composite materials using magnetic nano-particles to orient reinforcing particles and reinforced materials obtained using the method
  申请人：ETH Zurich

  公开号：EP2371522A1

  公开（公告）日：2011-10-05

  A method for making a composite material with non-spherical reinforcing particles embedded in a matrix, is disclosed. In this method, in a first step magnetic and/or superparamagnetic nanoparticles are attached to the non-spherical reinforcing particles, in a second step the resulting reinforcing particles are introduced into a liquid matrix material and/or a liquid matrix-precursor material, and in a third step the material of the matrix is solidified and/or polymerized and/or cross-linked. In accordance with the proposed invention prior to and/or during solidification and/or polymerization and/or cross-linking of the matrix material or the matrix precursor material, respectively, a magnetic field is applied so as to align the reinforcing particles in the matrix and this alignment is fixed in the matrix during and after the third step, wherein the non-spherical reinforcing particles preferably have a length (1) in one dimension of at least 0.5 µm and wherein the weight ratio of the nano-particles to the non-spherical reinforcing particles is below 0.25.

  本发明公开了一种在基体中嵌入非球形增强粒子的复合材料制造方法。在该方法中，第一步将磁性和/或超顺磁性纳米颗粒附着在非球形增强颗粒上，第二步将得到的增强颗粒引入液态基体材料和/或液态基体前驱体材料中，第三步使基体材料固化和/或聚合和/或交联。根据本发明的建议，在基体材料或基体前驱体材料分别固化和/或聚合和/或交联之前和/或期间，施加磁场以使增强粒子在基体中排列，并且在第三步期间和之后，这种排列固定在基体中，其中非球形增强粒子最好在一个维度上的长度（1）至少为 0.5 µm，并且纳米粒子与非球形增强粒子的重量比低于 0.25。
• WATER-BASED EXTRUSION PRIMER FOR POLYETHYLENE
  申请人：Henkel AG & Co. KGaA

  公开号：EP3699247A1

  公开（公告）日：2020-08-26

  The invention relates to a specific method of manufacturing a multilayer laminate. Additionally, the invention is directed to a multilayer laminate obtained by the method according to the invention and to the use of a specific aqueous coating composition comprising at least one specific copolymer as extrusion primer.

  本发明涉及一种制造多层层压板的特殊方法。此外，本发明还涉及一种通过本发明方法获得的多层层压板，以及使用一种包含至少一种特定共聚物的特定水性涂料组合物作为挤出底漆。
• Use of ureidomustine (BO-1055) in cancer treatment
  申请人：Academia Sinica

  公开号：US10548861B2

  公开（公告）日：2020-02-04

  Method of using ureidomustine (BO-1055), a water-soluble NDA cross-linking agent, in the treatment of a cancer, selected from the group consisting of various types of human leukemia [such as acute myeloid leukemia (ALL) and acute B Lymphoblastic leukemia (B-ALL)], lymphomas, small lung cell carcinoma (SCLC), sarcomas, and others.

  将水溶性NDA交联剂脲多莫司汀(BO-1055)用于治疗癌症的方法，该癌症选自各种类型的人类白血病[如急性髓性白血病(ALL)和急性B淋巴细胞白血病(B-ALL)]、淋巴瘤、小肺细胞癌(SCLC)、肉瘤等。
• Methods of assay
  申请人：SERONO DIAGNOSTICS LIMITED

  公开号：EP0167248B1

  公开（公告）日：1994-01-12