1-氰基-2-(4-羟基苯基)胍 | 138910-31-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 1-氰基-2-(4-羟基苯基)胍
• 英文名称: N-cyano-N'-(4-hydroxy-phenyl)-guanidine
• 英文别名: N-Cyan-N'-(4-hydroxy-phenyl)-guanidin；N-Cyano-N''-(4-hydroxyphenyl)guanidine；1-cyano-2-(4-hydroxyphenyl)guanidine
• CAS: 138910-31-3
• 化学式: C₈H₈N₄O
• 分子量: 176.178
• InChiKey: MIPYIOXKNPDVOX-UHFFFAOYSA-N

物化性质

• 沸点：
  314.5±44.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二氨腈 、 对氨基苯酚 生成 1-氰基-2-(4-羟基苯基)胍
  参考文献：
  名称：

  2-Guanidino-4(5)-p-chlorophenylimidazoles

  摘要：

  DOI：

  10.1021/ja01609a089

文献信息

• BRIDGED POLYCYCLIC COMPOUND BASED COMPOSITIONS FOR RENAL THERAPY
  申请人：Whiteford Jeffery A.

  公开号：US20100004218A1

  公开（公告）日：2010-01-07

  A pharmaceutically active agent, a pharmaceutically active agent carrier and method of use thereof are described. In some embodiments, a system may include a composition. The composition may include one or more bridged polycyclic compounds. At least one of the bridged polycyclic compounds may include at least two cyclic groups, and at least two pharmaceutically active agents may be associated with the bridged polycyclic compound. In some embodiments, one or more bridged polycyclic compounds may be administered to a subject to control fluid and/or waste levels.

  描述了一种药用活性剂、一种药用活性剂载体及其使用方法。在一些实施例中，系统可能包括一种组合物。该组合物可能包括一个或多个桥联多环化合物。至少一个桥联多环化合物可能包括至少两个环状基团，并且至少两种药用活性剂可能与桥联多环化合物相关联。在一些实施例中，一个或多个桥联多环化合物可以被用于控制主体的液体和/或废物水平。
• BRIDGED POLYCYCLIC COMPOUND BASED COMPOSITIONS FOR CONTROLLING CHOLESTEROL LEVELS
  申请人：Whiteford Jeffery A.

  公开号：US20100016270A1

  公开（公告）日：2010-01-21

  A pharmaceutically active agent, a pharmaceutically active agent carrier and method of use thereof are described. In some embodiments, a system may include a composition. The composition may include one or more bridged polycyclic compounds. At least one of the bridged polycyclic compounds may include at least two cyclic groups, and at least two pharmaceutically active agents may be associated with the bridged polycyclic compound. In some embodiments, one or more bridged polycyclic compounds may be administered to a subject to improve cardiac and/or cardiovascular health. In some embodiments, one or more bridged polycyclic compounds may be administered to a subject to control cholesterol levels.

  本文描述了一种药理活性剂、药理活性剂载体及其使用方法。在某些实施例中，该系统可能包括一种组合物。该组合物可能包括一个或多个桥接多环化合物。其中至少一个桥接多环化合物可能包括至少两个环状基团，并且至少有两种药理活性剂可能与桥接多环化合物相关联。在某些实施例中，可以向受试者施用一个或多个桥接多环化合物以改善心脏和/或心血管健康。在某些实施例中，可以向受试者施用一个或多个桥接多环化合物以控制胆固醇水平。
• Polymeric biocidal agents
  申请人：H.B. FULLER LICENSING & FINANCING, INC.

  公开号：EP0460385A2

  公开（公告）日：1991-12-11

  The resulting polymers are useful in any varity of applications requiring an antimicrobial agent or an active sanitizer or disinfectant including caulks, mortars, films and coatings, adhesives and the like. The polymers of this invention are also useful in medical, food preparation and personal are product applications.

  由此产生的聚合物可用于任何需要抗菌剂或活性消毒剂或消毒剂的应用领域，包括填缝剂、灰泥、薄膜和涂层、粘合剂等。本发明的聚合物还可用于医疗、食品制备和个人用品等领域。
• Biguanide derivatives and biocidal compositions containing them
  申请人：H.B. FULLER LICENSING & FINANCING, INC.

  公开号：EP0456093A2

  公开（公告）日：1991-11-13

  An antimicrobial compound comprising: wherein Q = phenylene; Y = -H or -methyl;         R = -(CF₂)yCF₃ wherein y = 1 - 20, -(CH₂)x-O-CxH2X+1 wherein x = 1 - 25, -(CH₂CH₂O)n(CH(CH₃)CH₂O)m (CH₂CH(CH₃)O)p(CH₂CH₂O)qT wherein T = -H or a branched or unbranched C₁₋₂₀ alkyl, n, m, p, q = 0 - 99 and n + m + p + q ≧ 1, -CHR'COOH wherein R' is a naturally occurring amino acid side chain, or (CH₂)xCOOH; and A = -H, -OH, NH₂, -CH₂ = CH₂, -(CH₂CH₂O)n(CH(CH₃)CH₂O)m(CH₂CH(CH₃)O)p(CH₂CH₂O)qT, an amine protein linkage, an amine saccharide linkage, a polyhydroxyamine linkage or -COOX wherein X = -H, an amino alcohol moiety, an amino alkoxy silane moiety, -CONH(CH₂)xCOOH, or -NHCH₂CH-(OX')₂ wherein X' = methyl or ethyl. Such novel biocidal compounds may also be combined with proteins and polysaccharides and are stable in a variety of solutions and in a typical biocidal regimen or treatment locus. The biocidal compounds of the invention exhibit an improved antibacterial effect on both gram positive and gram negative bacteria, can have biocidal activity against a variety of other microorganisms including virus, yeast, molds, etc., and can have activity against multi-cellular pests.

  一种抗菌化合物，包括 其中 Q = 亚苯基；Y = -H 或 -甲基； R = -(CF₂)yCF₃ 其中 y = 1 - 20，-(CH₂)x-O-CxH2X+1 其中 x = 1 - 25，-(CH₂CH₂O)n(CH(CH₃)CH₂O)m (CH₂CH(CH₃)O)p(CH₂CH₂O)qT 其中 T = -H 或支链或未支链 C₁₋₂₀ 烷基、 n、m、p、q = 0 - 99 且 n + m + p + q ≧ 1，-CHR'COOH，其中 R' 是天然存在的氨基酸侧链，或 (CH₂)xCOOH；和 A = -H、-OH、NH₂、-CH₂ = CH₂、-(CH₂CH₂O)n(CH(CH₃)CH₂O)m(CH₂CH(CH₃)O)p(CH₂CH₂O)qT、胺蛋白连接、胺糖连接、多羟胺连接或-COOX（其中 X = -H、氨基醇分子、氨基烷氧基硅烷分子、-CONH(CH₂)xCOOH 或-NHCH₂CH-(OX')₂（其中 X' = 甲基或乙基）。此类新型杀菌化合物还可与蛋白质和多糖结合，并在各种溶液和典型的杀菌方案或处理场所中保持稳定。本发明的杀菌化合物对革兰氏阳性菌和革兰氏阴性菌的抗菌效果都有所改善，对其他多种微生物包括病毒、酵母、霉菌等也有杀菌活性，对多细胞害虫也有活性。
• US5142010A
  申请人：——

  公开号：US5142010A

  公开（公告）日：1992-08-25