<(6-hydroxy-1-naphthylenyl)oxy>acetic acid | 72836-75-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: <(6-hydroxy-1-naphthylenyl)oxy>acetic acid
• 英文别名: 2-[(5-Hydroxy-2-naphthalenyl)oxy]acetic acid；2-(5-hydroxynaphthalen-2-yl)oxyacetic acid
• CAS: 72836-75-0
• 化学式: C₁₂H₁₀O₄
• 分子量: 218.209
• InChiKey: YNYBFKAWSBYIFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,6-二羟基萘 在 sodium hydroxide 、 potassium carbonate 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 4.0h， 生成 <(6-hydroxy-1-naphthylenyl)oxy>acetic acid
  参考文献：
  名称：

  Development of a Selective Enzyme-Linked Immunosorbent Assay for 1-Naphthol-the Major Metabolite of Carbaryl (1-Naphthyl N-Methylcarbamate)

  摘要：

  selective enzyme-linked immunosorbent assay for 1-naphthol was developed. Eight rabbits were immunized with either [(5-hydroxy-2-naphthylenyl)oxy]acetic acid (2b)-BSA, [(5-hydroxy-1-naphthylenyl)oxy]acetic acid (4)-BSA, or 5-hydroxy-2-naphthoic acid (7)-KLH, and all sera were screened against 14 different coating antigens. From this screening procedure, five assays could be developed, using two 7-KLH antisera, 3907 and 3909. The assay with the least interference and the best reliability (7-KLH antiserum 3907, 1:9000, and coating antigen 2b-BSA, 1.5 mu g/mL) was further optimized and characterized. It showed an I-50 value of about 72 mu g/L, with a range of detection from 10 to 1000 mu g/L. There was no cross-reactivity with carbaryl, which makes this assay very suitable for the selective detection of 1-naphthol, for example, in undiluted human urine and in soil extract. The assay was tested in organic solvents and showed a tolerance of at least 10% solvent (acetone, acetonitrile, methanol).

  DOI：

  10.1021/jf00040a019

文献信息

• Development of a Selective Enzyme-Linked Immunosorbent Assay for 1-Naphthol-the Major Metabolite of Carbaryl (1-Naphthyl N-Methylcarbamate)
  作者：Petra M. Kramer、Maria-Pilar Marco、Bruce D. Hammock

  DOI：10.1021/jf00040a019

  日期：1994.4

  selective enzyme-linked immunosorbent assay for 1-naphthol was developed. Eight rabbits were immunized with either [(5-hydroxy-2-naphthylenyl)oxy]acetic acid (2b)-BSA, [(5-hydroxy-1-naphthylenyl)oxy]acetic acid (4)-BSA, or 5-hydroxy-2-naphthoic acid (7)-KLH, and all sera were screened against 14 different coating antigens. From this screening procedure, five assays could be developed, using two 7-KLH antisera, 3907 and 3909. The assay with the least interference and the best reliability (7-KLH antiserum 3907, 1:9000, and coating antigen 2b-BSA, 1.5 mu g/mL) was further optimized and characterized. It showed an I-50 value of about 72 mu g/L, with a range of detection from 10 to 1000 mu g/L. There was no cross-reactivity with carbaryl, which makes this assay very suitable for the selective detection of 1-naphthol, for example, in undiluted human urine and in soil extract. The assay was tested in organic solvents and showed a tolerance of at least 10% solvent (acetone, acetonitrile, methanol).