(1R,2R)-N¹-(2-butyl)-1,2-diaminocyclohexane | 1258827-38-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1R,2R)-N¹-(2-butyl)-1,2-diaminocyclohexane
• 英文别名: (1R,2R)-2-N-butan-2-ylcyclohexane-1,2-diamine
• CAS: 1258827-38-1
• 化学式: C₁₀H₂₂N₂
• 分子量: 170.298
• InChiKey: YXJPOIKPPIPDBD-VXRWAFEHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1R,2R)-N¹-(2-butyl)-1,2-diaminocyclohexane 以 水 为溶剂， 反应 42.0h， 生成 cis-[(1R,2R)-N¹-(2-methylpropyl)-1,2-diaminocyclohexane-N,N'][(+)-camphorato-O,O']platinum(II)
  参考文献：
  名称：

  Synthesis and biological evaluation of platinum(II) complexes containing (1R,2R)-N1-alkyl-1,2-diaminocyclohexane and D-(+)-camphorate ligands

  摘要：

  Five platinum(II) complexes with N-monoalkyl derivatives of 1R,2R-diaminocyclohexane as ligands and D-(+)-camphorate anion as leaving group have been synthesized and characterized by elemental analysis, IR, H-1 NMR, ESI-MS, and HRMS spectra. All complexes were evaluated for their in vitro cytotoxicity against four human tumor cell lines and most of them showed promising cytotoxic activity, especially compounds 3 and 4 with branched alkyl substituent at one of nitrogen atoms. Preliminary mechanism study by flow cytometry and agarose gel electrophoresis was also carried out in comparison with cisplatin and oxaliplatin. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.10.011

文献信息

• Synthesis and antiproliferative activity of (1<i>R</i>,2<i>R</i>)-<i>N</i>¹-(2-butyl)-1,2-cyclohexanediamine platinum(II) complexes with malonate derivatives
  作者：Fengfan Liu、Zhiping Zhou、Shaohua Gou、Jian Zhao、Feihong Chen

  DOI：10.1080/00958972.2014.951638

  日期：2014.9.2

  Three new platinum(II) complexes of (1R,2R)-N-1-(2-butyl)-1,2-cyclohexanediamine with malonate derivatives as leaving groups have been synthesized and spectrally characterized. They were tested in vitro against four human cancer cell lines. [(1R,2R)-N-1-(2-butyl)-1,2-cyclohexanediamine-N,N '](2-ethylmalonato-O,O ')platinum(II) turned out to be more active (IC50=4.65 mu M) than oxaliplatin (IC50=6.55 mu M) against the MCF-7 cell line and is superior to its parent complex, [(1R,2R)-N-1-(2-butyl)-1,2-cyclohexanediamine-N,N '](malonato-O,O ')platinum(II). In addition, agarose gel electrophoresis study revealed that the interaction of the complex with pET22b plasmid DNA had a different behavior from that of cisplatin or oxaliplatin.