3H-Imidazo<4,5-b>pyridin-7(4H)-thion | 1421-25-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 3H-Imidazo<4,5-b>pyridin-7(4H)-thion
• 英文别名: 1,4-dihydro-imidazo[4,5-b]pyridine-7-thione；3H-Imidazo[4,5-b]pyridine-7-thiol；1,4-dihydroimidazo[4,5-b]pyridine-7-thione
• CAS: 1421-25-6
• 化学式: C₆H₅N₃S
• 分子量: 151.192
• InChiKey: ZJKISMRQYQWJJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• 4-Azaindole compounds
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10730877B2

  公开（公告）日：2020-08-04

  Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

  公开了式 (I) 的化合物 其中 G、A、R1、R5 和 n 在本文中定义。还公开了使用此类化合物作为通过 Toll 样受体 7 或 8 或 9 发出信号的抑制剂的方法，以及包含此类化合物的药物组合物。这些化合物可用于治疗炎症和自身免疫性疾病。
• 4-AZAINDOLE COMPOUNDS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20200095247A1

  公开（公告）日：2020-03-26

  Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R 1 , R 5 , and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
• POLYCYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS
  申请人：Revolution Medicines, Inc.

  公开号：US20200407372A1

  公开（公告）日：2020-12-31

  The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.