4-氨基-6-甲基-2(1H)-蝶啶酮 | 89792-49-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 中文名称: 4-氨基-6-甲基-2(1H)-蝶啶酮
• 中文别名: 2(1H)-蝶啶酮,4-氨基-6-甲基-
• 英文名称: 6-Methylisopterin
• 英文别名: 4-amino-6-methyl-pteridine-2-one；4-Amino-6-methylpteridin-2(3H)-one；4-amino-6-methyl-3H-pteridin-2-one
• CAS: 89792-49-4
• 化学式: C₇H₇N₅O
• 分子量: 177.165
• InChiKey: XSYFTQXDJHQAHC-UHFFFAOYSA-N

物化性质

• 沸点：
  335.8±25.0 °C(Predicted)
• 密度：
  1.76±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  92.2
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  4,5,6-triamino-pyrimidine-2-one hydrochloride 、 水 、 2-氧代丙醛-1-肟 以 硫酸 为溶剂， 生成 4-氨基-6-甲基-2(1H)-蝶啶酮
  参考文献：
  名称：

  Pteridine nucleotide analogs as fluorescent DNA probes

  摘要：

  本发明提供了一种新颖的蝶啶核苷酸，它们在生理条件下具有高度的荧光性，并可用于化学合成荧光寡核苷酸。本发明还提供了包含一个或多个蝶啶核苷酸的荧光寡核苷酸。此外，本发明还提供了蝶啶核苷三磷酸，可用作DNA扩增程序中的构成单体。

  公开号：

  US05525711A1

文献信息

• PTERIDINE NUCLEOTIDE ANALOGS AS FLUORESCENT DNA PROBES
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP0759927A1

  公开（公告）日：1997-03-05
• Fluorescent base analogues' usage in the characterization of nucleic acid molecules and their interactions
  申请人：Chen Yaodong

  公开号：US20080020378A1

  公开（公告）日：2008-01-24

  This invention provides methods, apparatus and kits for the quantitative and qualitative characterization of the nucleic acid molecule's behavior by modify the nucleic acid molecules to incorporate selected fluorescent base analogues (FBAs). The methods generally place one or more fluorescent base analogue into a nucleic acid molecule (e.g., an oligonucleotide) to replace the corresponding normal base(s), arrange fluorescent base analogues as intrinsic fluorescent probes by using direct excitation, indirect excitation, and excimer emission labeling schemes, introducing so modified nucleic acid molecules into the matrix with interested condition and measuring the fluorescent properties of the modified nucleic acid molecules at the specific emission wavelength of FBA(s). The apparatus is designed to irradiate the FBA(s) incorporated nucleic acid molecule at a wavelength in the range of 240 nm-280 nm and detect the fluorescent activities at the specific emission wavelength of the respective FBA(s). The kit provides oligonucleotides modified by multiple FBAs in the position of critical portions. It utilizes simultaneous indirect excitation labeling scheme for qualitative and quantitative investigation of nucleic acid molecules' interaction in vitro and in vivo.
• Methods to create fluorescent biosensors using aptamers with fluorescent base analogs
  申请人：Katilius Evaldas

  公开号：US20090054250A1

  公开（公告）日：2009-02-26

  The present invention provides improved methods for generating fluorescent aptamer polynucleotides, novel polynucleotides, and methods for use thereof.
• Self-Assembled Combinatorial Encoding Nanoarrays for Multiplexed Biosensing
  申请人：Yan Hao

  公开号：US20100009868A1

  公开（公告）日：2010-01-14

  The present invention provides combinatorial encoding nucleic acid tiling arrays and methods for their use and synthesis.
• NUCLEIC ACID BINDING ASSAYS
  申请人：Hermann Thomas

  公开号：US20100197041A1

  公开（公告）日：2010-08-05

  This invention relates to methods for screening compounds for the ability to interact with a nucleic acid target, assay kits useful thereof and compositions regarding same. In a particular aspect, the invention relates to specific binding assays employing fluorescent label(s). The methods involve assessing the conformation of nuclei acid targets in the presence and absence of test compounds, and identifying as a ligand any test ligand that causes a measurable conformation change in nuclei acid targets. The effect of compounds on target nuclei acids conformation is assessed by measuring the fluorescence changes of a fluorescently label(s) attached hereto.