4-氨基-6-甲基-8-(2-脱氧-beta-D-呋喃核糖基)-7(8H)-蝶啶酮 | 195442-55-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 中文名称: 4-氨基-6-甲基-8-(2-脱氧-beta-D-呋喃核糖基)-7(8H)-蝶啶酮
• 中文别名: 4-氨基-8-[(2R,4R,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基]-6-甲基-蝶啶-7-酮
• 英文名称: 6MAP
• 英文别名: 4-Amino-6-methyl-8-(2-deoxy-beta-D-ribofuranosyl)-7(8H)-pteridone；4-amino-8-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-methylpteridin-7-one
• CAS: 195442-55-8
• 化学式: C₁₂H₁₅N₅O₄
• 分子量: 293.282
• InChiKey: MHIOPDSMXLCBHH-XLPZGREQSA-N

物化性质

• 熔点：
  >190°C dec.

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  134
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  4-氨基-6-甲基-8-(2-脱氧-beta-D-呋喃核糖基)-7(8H)-蝶啶酮 在 吡啶 、 四氮唑 作用下， 以 二氯甲烷 为溶剂， 生成 Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(4-amino-6-methyl-7-oxo-7H-pteridin-8-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
  参考文献：
  名称：

  Pteridine Nucleosides Analogs of 2′-Deoxyadenosine as Building Blocks for Oligonucleotide Synthesis

  摘要：

  The synthesis, configuration and conformation of adenosine analogous pteridine nucleosides and their conversion into the monomeric building blocks for the automated application in an DNA synthesizer is described.

  DOI：

  10.1080/07328319708002964
• 作为产物：
  描述：

  [(2R,3S,5R)-5-(4-amino-6-methyl-7-oxopteridin-8-yl)-3-(4-chlorobenzoyl)oxyoxolan-2-yl]methyl 4-chlorobenzoate 在 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 4-氨基-6-甲基-8-(2-脱氧-beta-D-呋喃核糖基)-7(8H)-蝶啶酮
  参考文献：
  名称：

  Pteridine Nucleosides Analogs of 2′-Deoxyadenosine as Building Blocks for Oligonucleotide Synthesis

  摘要：

  The synthesis, configuration and conformation of adenosine analogous pteridine nucleosides and their conversion into the monomeric building blocks for the automated application in an DNA synthesizer is described.

  DOI：

  10.1080/07328319708002964

文献信息

• A FLUORESCENT CYCLIC DINUCLEOTIDE AND ITS USE IN METHODS OF IDENTIFYING SUBSTANCES HAVING AN ABILITY TO MODULATE THE CGAS/STING PATHWAY
  申请人：Ludwig-Maximilians-Universität München

  公开号：EP3431484A1

  公开（公告）日：2019-01-23

  The present invention relates to a non-canonical cyclic di-nucleotide containing an asymmetric 2'-5' and 3'-5' phosphodiester linkage and its use in a method for identifying a substance having an ability to modulate cGAS activity or bind to STING. Furthermore, the cyclic dinucleotide is used in a method of identifying a substance having an ability to modulate the activity of a 2'-5' phosphodiesterase.

  本发明涉及一种含有不对称 2'-5'和 3'-5'磷酸二酯连接的非经典环状二核苷酸及其在鉴定具有调节 cGAS 活性或与 STING 结合能力的物质的方法中的用途。此外，环状二核苷酸还可用于鉴定具有调节 2'-5' 磷酸二酯酶活性的物质的方法。
• Exosomal biomarkers diagnostic of tuberculosis
  申请人：University of Notre Dame du Lac

  公开号：US10889868B2

  公开（公告）日：2021-01-12

  A method for diagnosing an active Mycobacterium tuberculosis infection by detecting certain RNA biomarkers present in secreted extracellular vesicles isolated from a bodily fluid. The RNA biomarkers in the secreted extracellular vesicles may include a certain Mycobacterium RNAs as well as certain host cell RNAs. Also provided is an RNA signature of certain Mycobacterium and host cell RNA present in secreted extracellular vesicles indicative of an active tuberculosis infection.

  一种通过检测从体液中分离出来的分泌性细胞外囊泡中存在的某些 RNA 生物标记物来诊断活动性结核分枝杆菌感染的方法。分泌的细胞外囊泡中的 RNA 生物标志物可包括某些分枝杆菌 RNA 和某些宿主细胞 RNA。此外，还提供了分泌性细胞外囊泡中存在的某些分枝杆菌和宿主细胞 RNA 的 RNA 标志，表明结核病感染处于活跃期。
• PTERIDINE NUCLEOTIDE ANALOGS
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary of the Department of Health and Human Services

  公开号：EP1112281B1

  公开（公告）日：2005-11-23
• EXOSOMAL BIOMARKERS DIAGNOSTIC OF TUBERCULOSIS
  申请人：University of Notre Dame du Lac

  公开号：US20170253916A1

  公开（公告）日：2017-09-07

  The disclosure provides a method for diagnosing an active mycobacterium tuberculosis infection by detecting certain RNA biomarkers present in secreted extracellular vesicles isolated from a bodily fluid. The RNA biomarkers in the secreted extracellular vesicles may include a certain mycobacterium RNAs as well as certain host cell RNAs. Also provided is an RNA signature of certain mycobacterium and host cell RNA present in secreted extracellular vesicles indicative of an active tuberculosis infection.
• US6716971B1
  申请人：——

  公开号：US6716971B1

  公开（公告）日：2004-04-06