1-(1,2,3,4-tetrahydroisoquinolin-1-yl)naphthalene-2,3-diol | 948858-03-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1-(1,2,3,4-tetrahydroisoquinolin-1-yl)naphthalene-2,3-diol
• 英文别名: 1-(1,2,3,4-Tetrahydroisoquinolin-1-yl)naphthalene-2,3-diol
• CAS: 948858-03-5
• 化学式: C₁₉H₁₇NO₂
• 分子量: 291.349
• InChiKey: DFWNMIDWBWQHBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,4-二氢异喹啉 、 2,3-二羟基萘 以 水 为溶剂， 以89%的产率得到1-(1,2,3,4-tetrahydroisoquinolin-1-yl)naphthalene-2,3-diol
  参考文献：
  名称：

  Self-catalytic, solvent-free or in/on water protocol: aza-Friedel–Crafts reactions between 3,4-dihydroisoquinoline and 1- or 2-naphthols

  摘要：

  A self-catalytic protocol was developed using an aza-Friedel-Crafts method to generate 1-naphthoyl tetrahydroisoquinoline products under solvent-free conditions or in/on water. Yields were increased with the use of water. The reaction proceeded with 100% atom economy in the absence of any additional catalyst. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.11.008

文献信息

• Self-catalytic, solvent-free or in/on water protocol: aza-Friedel–Crafts reactions between 3,4-dihydroisoquinoline and 1- or 2-naphthols
  作者：Patricia D. MacLeod、Zhiping Li、Chao-Jun Li

  DOI：10.1016/j.tet.2009.11.008

  日期：2010.1

  A self-catalytic protocol was developed using an aza-Friedel-Crafts method to generate 1-naphthoyl tetrahydroisoquinoline products under solvent-free conditions or in/on water. Yields were increased with the use of water. The reaction proceeded with 100% atom economy in the absence of any additional catalyst. (C) 2009 Elsevier Ltd. All rights reserved.