4-acetylamino-N-(5,6,7,8-tetrahydro-quinazolin-2-yl)-benzenesulfonamide | 651756-28-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-acetylamino-N-(5,6,7,8-tetrahydro-quinazolin-2-yl)-benzenesulfonamide
• 英文别名: 4-acetylamino-N-(5,6,7,8-tetrahydro-quinazolin-2-yl)-benzenesulfonamide；N-acetyl-sulfanilic acid-(5,6,7,8-tetrahydro-quinazolin-2-ylamide)；N-Acetyl-sulfanilsaeure-(5,6,7,8-tetrahydro-chinazolin-2-ylamid)
• CAS: 651756-28-4
• 化学式: C₁₆H₁₈N₄O₃S
• 分子量: 346.41
• InChiKey: VTTSAZBRAWJWCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.11
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  101.05
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  4-acetylamino-N-(5,6,7,8-tetrahydro-quinazolin-2-yl)-benzenesulfonamide 在 sodium hydroxide 作用下， 生成 4-amino-N-(5,6,7,8-tetrahydro-quinazolin-2-yl)-benzenesulfonamide
  参考文献：
  名称：

  N¹-Sulfanilylamino-alkyl-pyrimidines

  摘要：

  DOI：

  10.1021/ja01262a034
• 作为产物：
  描述：

  5,6,7,8-四氢喹唑啉-2-胺 、 对乙酰胺基苯磺酰氯 生成 4-acetylamino-N-(5,6,7,8-tetrahydro-quinazolin-2-yl)-benzenesulfonamide
  参考文献：
  名称：

  Sulfonamido Derivatives of Pyrimidines

  摘要：

  DOI：

  10.1021/ja01856a046

文献信息

• Substituted 2-Sulfanilamidopyrimidines
  作者：William T. Caldwell、Edmund C. Kornfeld、Conard K. Donnell

  DOI：10.1021/ja01853a045

  日期：1941.8
• Sugasawa; Ban; Mochizuki, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1949, vol. 69, p. 82,84
  作者：Sugasawa、Ban、Mochizuki

  DOI：——

  日期：——
• Prevalance of Functional Blindness, Visual Impairment, and Related Functional Deficits Among Elderly Mexican Americans
  作者：A. R. DiNuzzo、S. A. Black、M. J. Lichtenstein、K. S. Markides

  DOI：10.1093/gerona/56.9.m548

  日期：2001.9.1

  Background. This report describes the prevalence and correlates of functional blindness and visual impairment among older Mexican Americans, using data on 2800 respondents from the Hispanic Established Populations for the Epidemiological Study of the Elderly.Methods. Bivariate and multivariate logistic regression analyses were used to examine the associations between corrected bilateral distant vision and sociodemographic characteristics, selected health conditions, self-reported health status. health care utilization, and functional dependence on the basis of assistance needed for basic and instrumental activities of daily living (ADLs).Results. Using a modified Snellen test for distance visual acuity, 5% of older Mexican Americans were found to be functionally blind. and 13.5% were found to be visually impaired. Vision loss was significantly associated with older age, lower education, hypertension, diabetes, poor self-rated health, and hospitalization during the year prior to the interview. Over 50% of functionally blind subjects required assistance with at least one basic ADL, compared with 15% of those who were visually impaired and 8% of those who were not visually impaired.Conclusions. The prevalence of functional blindness in this sample of elderly Mexican Americans was higher than reported for the general elderly population, yet they also have higher rates of adequate vision because of the low prevalence of visual impairment, The results suggest a need for more research on the prevalence and impact of functional blindness and Visual impairment on the health of older Mexican Americans.