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4-methyl-1H-2-benzopyran | 32727-59-6

中文名称
——
中文别名
——
英文名称
4-methyl-1H-2-benzopyran
英文别名
4-methylisochromene;4-methyl-1H-isochromene;4-Methyl-isobenzopyran;4-methyl-1H-isochromene
4-methyl-1H-2-benzopyran化学式
CAS
32727-59-6
化学式
C10H10O
mdl
MFCD18450575
分子量
146.189
InChiKey
GLFVCAAZLNKMIU-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    1.9
  • 重原子数:
    11
  • 可旋转键数:
    0
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.2
  • 拓扑面积:
    9.2
  • 氢给体数:
    0
  • 氢受体数:
    1

反应信息

  • 作为反应物:
    描述:
    4-methyl-1H-2-benzopyran 为溶剂, 反应 0.5h, 生成 2-甲基苯乙烯
    参考文献:
    名称:
    Photochemistry of 4-methylisochromene and 1,5-hydrogen migration in the resulting o-xylylene
    摘要:
    DOI:
    10.1021/jo01305a036
  • 作为产物:
    描述:
    烯丙基-2-溴苯甲基醚 在 palladium diacetate 四乙基氯化铵 、 sodium formate 、 sodium acetate 作用下, 以 N,N-二甲基甲酰胺 为溶剂, 以74%的产率得到4-methyl-1H-2-benzopyran
    参考文献:
    名称:
    通过无配体钯催化的还原性Heck环化反应合成杂环
    摘要:
    五个和六个成员的杂环,二氢吲哚,2,3-二氢苯并呋喃,苯并二氢吡喃,异苯并二氢吡喃,1,2,3,4-四氢喹啉和1,2,3,4-四氢异喹啉的合成,配体的收率为70-99%据报道,在温和的条件下,无钯钯催化的苯基溴化物和氯化物的还原性Heck环化反应。发现水对于这些反应是必不可少的。
    DOI:
    10.1016/j.tetlet.2007.01.156
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文献信息

  • Copper-catalyzed oxidative cleavage of carbon–carbon double bond of enol ethers with molecular oxygen
    作者:Makoto Tokunaga、Yuki Shirogane、Hiroshi Aoyama、Yasushi Obora、Yasushi Tsuji
    DOI:10.1016/j.jorganchem.2005.05.018
    日期:2005.11
    A novel CC bond cleavage reaction of aromatic enol ethers (1) to give ketones (2) using molecular oxygen as oxidant is described. Among the examined catalysts (Cu(II), Pd(II), Ru(II), and H+), CuCl2 exhibited the highest activity. The reaction proceeded smoothly with several kinds of substrates.
    描述了一种新型的使用分子氧作为氧化剂的芳香族烯醇醚(1)的CC键裂解反应,生成酮(2)的方法。在所研究的催化剂(Cu(II),Pd(II),Ru(II)和H +)中,CuCl 2表现出最高的活性。反应在几种底物上顺利进行。
  • Molybdenum-Catalyzed Stannylations as Key Steps in Heterocyclic Synthesis
    作者:Sascha Braune、Matthias Pohlman、Uli Kazmaier
    DOI:10.1021/jo035406j
    日期:2004.1.1
    THF/carbonyl complexes of molybdenum and tungsten are suitable precursors for the synthesis of the corresponding monoisonitrile carbonyl complexes. Whereas complexes with electron-rich isonitriles are suitable for regioselective hydrostannations, complexes with electron-poor isonitriles are efficient catalysts for distannations, without reduction of aromatic halides. This allows for the synthesis of
    钼和钨的THF /羰基配合物是用于合成相应的单异腈羰基配合物的合适的前体。具有富电子异腈的配合物适用于区域选择性氢化锡烷基化,而具有贫电子异腈的配合物是用于脱锡的有效催化剂,而不会还原芳族卤化物。这允许合成卤代的二苯甲酰化的烯丙基醚,其可以进行分子内Stille偶联,产生杂环,可以在剩余的苯乙烯基上进一步修饰。
  • 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles
    申请人:Tsubouchi Hidetsugu
    公开号:US20060094767A1
    公开(公告)日:2006-05-04
    The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R 1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R 2 represents a group —OR 3 or the like, and R 3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R 1 and —(CH 2 ) n R 2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): wherein R 41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis , multi-drug-resistant Mycobacterium tuberculosis , and atypical acid-fast bacteria.
    本发明提供了一种2,3-二氢-6-硝基咪唑并[2,1-b]噁唑化合物,其通式如下:其中,R1代表氢原子或C1-C6烷基,n代表0到6的整数,R2代表—OR3或类似的基团,R3代表氢原子、C1-C6烷基或类似的基团,或者R1和—(CH2)nR2可以通过相邻的碳原子通过氮原子结合在一起形成一个螺环,其通式为(H):其中,R41为氢、C1-C6烷基或类似的基团。该化合物对结核分枝杆菌、多药耐药结核分枝杆菌和非典型酸性快速细菌具有优异的杀菌作用。
  • 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES
    申请人:OTSUKA PHARMACEUTICAL CO., LTD.
    公开号:EP1555267A1
    公开(公告)日:2005-07-20
    The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R2 represents a group -OR3 or the like, and R3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R1 and -(CH2)nR2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): wherein R41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and a typical acid-fast bacteria.
    本发明提供了由以下通式代表的 2,3-二氢-6-硝基咪唑并[2,1-b]恶唑化合物: 其中R1代表氢原子或C1-C6烷基,n代表0至6的整数,R2代表基团-OR3或类似基团,R3代表氢原子、C1-C6烷基或类似基团,或者R1和-(CH2)nR2可以通过氮原子与相邻的碳原子相互结合,从而形成通式(H)代表的螺环: 其中 R41 为氢、C1-C6 烷基或类似基团。本化合物对结核分枝杆菌、多重耐药结核分枝杆菌和典型的耐酸细菌有很好的杀菌作用。
  • 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound
    申请人:OTSUKA PHARMACEUTICAL CO., LTD.
    公开号:EP2570418A2
    公开(公告)日:2013-03-20
    The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R2 represents a group -OR3 or the like, and R3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R1 and -(CH2)nR2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): wherein R41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.
    本发明提供了一种由以下通式表示的 2,3-二氢-6-硝基咪唑并[2,1-b]恶唑化合物: 其中R1代表氢原子或C1-C6烷基,n代表0至6的整数,R2代表基团-OR3或类似基团,R3代表氢原子、C1-C6烷基或类似基团,或者R1和-(CH2)nR2可以通过氮原子与相邻的碳原子相互结合,从而形成通式(H)代表的螺环: 其中 R41 为氢、C1-C6 烷基或类似基团。本化合物对结核分枝杆菌、多重耐药结核分枝杆菌和非典型耐酸菌有很好的杀菌作用。
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