Naproxen | 37507-96-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Naproxen
• 英文别名: d-2-(6-methoxy-naphthyl)propionic acid；2-(6-methoxynaphthyl)propionic acid；6-methoxy-α-methyl naphthaleneacetic acid；6-methoxy-a-methyl naphthaleneacetic acid；alpha-(6-methoxy)naphthyl-propionic acid；2-(6-Methoxynaphthalen-1-yl)propanoic acid
• CAS: 37507-96-3
• 化学式: C₁₄H₁₄O₃
• 分子量: 230.263
• InChiKey: XQMPFCWHEKIBNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(5-hydroxy-2,4,6,7-tetramethyl-2,3-dihydrobenzofuran-2-yl)ethanol 、 Naproxen 、 2-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 四氢呋喃 在 氮 、 水 、 Sodium sulfate-III 作用下， 以 乙酸乙酯 为溶剂， 反应 24.0h， 以to give 1.84 g (74.5% yield) of a foam residue的产率得到2-(5-Hydroxy-2,4,6,7-tetramethyl-3,4-dihydro-benzo[1,2-b]furan-2yl)ethyl 2-(6-methoxy-2-naphthyl)propionate
  参考文献：
  名称：

  Esters and amides of non-steroidal anti-inflammatory carboxylic acids

  摘要：

  本发明揭示了具有抗炎和抗氧化活性的化合物。这些化合物通过多种机制在预防和治疗炎症性疾病方面具有用处。本发明还揭示了利用这些化合物的特性进行治疗的方法以及相应的制药组合物。

  公开号：

  US05607966A1
• 作为产物：
  描述：

  6-甲氧基-3,4-二氢-1H-2-萘酮 、 三苯基膦 、 、 、 Ethyl 2-<1-(6-Methoxynaphthyl)>propionate 以affords 6-methoxynaphthyl-α-methylacetic acid的产率得到Naproxen
  参考文献：
  名称：

  2-Naphthyl acetic acid derivatives and compositions and methods thereof

  摘要：

  2-萘乙酸衍生物及其对应的酰胺、酯、羟肟酸和加成盐，在乙酸部分的α-位置和/或在萘环的1、4、6、7或8位置，以及在3和4位置可选择饱和，这些化合物具有抗炎、镇痛、退烧和止痒作用。通过给予萘乙酸衍生物的途径来治疗炎症、疼痛、发热和瘙痒的药物方法。用于治疗上述疾病的药物组合物包括萘乙酸衍生物。

  公开号：

  US03978116A1

文献信息

• 6-Substituted 2-naphthyl .alpha.-substituted acetamides
  申请人：Syntex Corporation

  公开号：US03978124A1

  公开（公告）日：1976-08-31

  2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

  2-萘乙酸衍生物及其相应的酰胺、酯、羟肟酸和加成盐，可在乙酸基团的α-位置和/或在萘环的1、4、6、7或8位置上选择性地取代，并可在3和4位置上选择性地饱和。它们是抗炎、镇痛、退热和止痒剂。一种通过给予萘乙酸衍生物治疗炎症、疼痛、发热和瘙痒的药物方法。一种用于治疗上述疾病的药物组合物，包括萘乙酸衍生物。
• 2-Naphthyl acetic acid derivatives
  申请人：Syntex Corporation

  公开号：US03980699A1

  公开（公告）日：1976-09-14

  2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

  2-萘乙酸衍生物及其相应的酰胺、酯、羟肟酸和加成盐，可选择在乙酸基团的α-位置和/或在萘环的1、4、6、7或8号位上进行取代，可选择在3和4号位饱和，具有抗炎、镇痛、退热和止痒作用。一种通过给予萘乙酸衍生物来治疗炎症、疼痛、发热和瘙痒的药物方法。一种用于治疗上述疾病的药物组合物，包括萘乙酸衍生物。
• Anti-inflammatory, analgesic, anti-pyretic and anti-pruritic
  申请人：Syntex Corporation

  公开号：US03998966A1

  公开（公告）日：1976-12-21

  2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

  2-萘乙酸衍生物及其相应的酰胺、酯、羟肟酸和加成盐，在乙酸基团的α-位和/或萘环的1、4、6、7或8位可能被取代，且在3和4位可能被饱和，具有抗炎、镇痛、退热和止痒作用。使用萘乙酸衍生物的药物治疗方法，用于治疗炎症、疼痛、发热和瘙痒。一种用于治疗上述疾病的药物组合物，包括萘乙酸衍生物。
• 6-Substituted 2-naphthyl acetic acid derivatives
  申请人：Syntex Corporation

  公开号：US04001301A1

  公开（公告）日：1977-01-04

  2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, antipyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

  2-萘乙酸衍生物及其相应的酰胺、酯、羟肟酸和加成盐，可选地在乙酸基团的α-位置和/或在萘环的1、4、6、7或8号位置取代，并可选地在3号和4号位置饱和，具有抗炎、镇痛、退热和抗瘙痒作用。一种通过给予萘乙酸衍生物治疗炎症、疼痛、发热和瘙痒的药物方法。一种用于治疗上述疾病的药物组合物，包括萘乙酸衍生物。
• Systemic administration of esters and amides of antioxidants which may
  申请人：Alcon Laboratories, Inc.

  公开号：US05643943A1

  公开（公告）日：1997-07-01

  Methods for treating vascular inflammatory pathologies are disclosed. Particularly, the methods utilize pharmaceutical compositions containing certain compounds having an anti-inflammatory and anti-oxidant moiety covalently linked by an amide or ester bond. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms.

  公开了治疗血管炎症病理的方法。特别地，该方法利用含有某些化合物的药物组合物，该化合物具有抗炎和抗氧化基团，通过酰胺或酯键共价连接。这些化合物通过多种机制有助于预防和治疗炎症性疾病。