A Raman scattering probe, and a method of making such a probe, uses a capsule of nanometric size, such as a nanotube, to which is coupled at least one Raman-active molecule. The Raman-active molecule may be encapsulated in, or attached on the exterior of, the capsule, and exhibits a Raman scattering response when the probe is illuminated by an excitation light beam. A functionalization chemical group that is attached to an exterior of the capsule provides a connection between the capsule and a target material. This functionalization may include a generic chemical functionalization that bonds with any of a plurality of secondary chemical groups each of which bonds directly with a different target. A method of using the probe for Raman spectroscopy or Raman imaging is also provided.
                            一种拉曼散射探针和制造这种探针的方法使用纳米尺寸的胶囊,如纳米管,胶囊上耦合有至少一个拉曼活性分子。拉曼活性分子可封装在胶囊中或附着在胶囊外部,当探针被激发光束照射时,会产生拉曼散射响应。附着在胶囊外部的官能化
化学基团提供了胶囊与目标材料之间的连接。这种官能化可以包括通用的
化学官能化,与多个次级
化学基团中的任何一个结合,每个次级
化学基团直接与不同的靶材结合。此外,还提供了一种将探针用于拉曼光谱或拉曼成像的方法。