3β-hydroxycholest-5-en-4β-yl benzoate | 50391-80-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β-hydroxycholest-5-en-4β-yl benzoate
• 英文别名: benzoic acid-(3β-hydroxy-cholesten-(5)-yl-(4β)-ester)；Benzoesaeure-(3β-hydroxy-cholesten-(5)-yl-(4β)-ester)；Hydroxy-3β-benzoxy-4β-cholesten-5
• CAS: 50391-80-5
• 化学式: C₃₄H₅₀O₃
• 分子量: 506.769
• InChiKey: XQMZHTLFJFBQBX-GQNSFCSSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.22
• 重原子数：
  37.0
• 可旋转键数：
  7.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  3β-hydroxycholest-5-en-4β-yl benzoate 生成 cholest-5-ene-3β,4β-diyl diacetate
  参考文献：
  名称：

  Lorne,R.; Julia,S., Bulletin de la Societe Chimique de France, 1973, p. 1357 - 1368

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 、 potassium acetate 作用下， 生成 3β-hydroxycholest-5-en-4β-yl benzoate
  参考文献：
  名称：

  Mortality and socioeconomic indicators in Spain 1962-1991

  摘要：

  背景：研究目标是描述西班牙各省 (n=50) 的死亡率和一些社会经济指标的演变，以量化其关联并评估这些社会经济因素解释西班牙各省在此期间死亡率水平的能力1962 年至 1991 年。方法：进行了一项生态横断面研究，以评估西班牙一些社会经济指标与死亡率之间的关系。有关男女、全因、年龄调整死亡率和婴儿死亡率、人均国民生产总值、经济活动人口和失业率、人口密度、公立医院功能性床位和公立小学单位的数据是在省级汇总水平上获得的。计算所有这些指标的收敛 σ 系数，并拟合死亡率的简单和多元线性回归模型。结果与结论：结果表明，在研究期间，各省间死亡率下降，社会经济指标趋同，但各省间死亡率差异并未缩小。在整个研究期间，失业或经济水平等社会经济因素（通过国民生产总值衡量）始终与死亡率相关。

  DOI：

  10.1093/eurpub/10.4.268

文献信息

• Polyglucosan body disease in a mixed-breed dog
  作者：RD Jolly、FI Hill、JA Hill、GN Mehrtens、PM Davey、DH Hopcroft

  DOI：10.1080/00480169.2002.36247

  日期：2002.1.2

  AIM: To describe the histopathology of a previously unrecorded canine disease and deduce the cause of the lesions.METHODS: Formalin-fixed tissues were processed into paraffin wax and epoxy resin for light and electron microscopy of variously stained sections of liver, brain, heart muscle and kidney.RESULTS: Periodic acid Schiff (PAS)-positive bodies in liver and myocardium were typical of a polyglucosan body disease. Neurons contained coarse granular material that stained similarly to the polyglucosan bodies.CONCLUSION: The nature, distribution and histochemistry of lesions observed are consistent with a putative diagnosis of Glycogen storage disease type IV, an inherited metabolic defect associated with a deficiency of glycogen-branching enzyme not previously reported in dogs.
• Blood pressure, heart rate, hormonal and other acute responses to rubber-ring castration and tail docking of lambs
  作者：A Peers、DJ Mellor、EM Wintour、M Dodic

  DOI：10.1080/00480169.2002.36251

  日期：2002.4

  AIM: To examine cardiovascular, hormonal and other physiological responses of 2-month-old lambs to rubber-ring castration and tail docking.METHODS: Twenty-two male lambs, well accustomed to handling and prepared with femoral artery and jugular vein cannulae, were studied during a 5 h control period and, at least 2 days later, for 1 h before and 4 h after castration and tail docking using rubber rings. Pressure recordings were made via femoral cannulae and blood samples for analysis of plasma constituents were taken from jugular cannulae.RESULTS: Mean systolic, diastolic and mean arterial blood pressure, heart rate and the plasma concentrations of adrenocorticotropic hormone (ACTH) and cortisol all increased markedly during the first 1 h after ring castration and tail docking. Although plasma ACTH and cortisol concentrations had returned to control levels by 2.5-3 h, blood pressures and heart rate were still elevated 4 h after ring application. In contrast, there were no significant changes in mean plasma concentrations of renin, electrolytes, minerals, glucose, lactate, urea, creatinine, total carbon dioxide and total proteins, plasma osmolality or the haematocrit after ring application. There were no significant changes in the mean values for any parameter during the 5 h control period or the I h period before ring application.CONCLUSION: Systolic, diastolic and mean arterial blood pressure and heart rate may be more sensitive than plasma ACTH or cortisol concentrations as indices of low-grade pain induced by ring castration and tail docking. Alternatively, it is possible that by 4 h after ring placement a small shift in sympathetic tone still persists in the absence of low-grade pain.