ciprofloxacin | 1348448-77-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: ciprofloxacin
• 英文别名: Neofloxin；Ciloxan；Cipro；CFI；CIP；4-cyclopropyl-7-fluoro-1-oxo-6-piperazin-1-yl-4H-naphthalene-2-carboxylic acid
• CAS: 1348448-77-0
• 化学式: C₁₈H₁₉FN₂O₃
• 分子量: 330.359
• InChiKey: ZRIBFIVUFNVETD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  copper(II) nitrate trihydrate 、 2-bromo-7-hydroxy-10,11-dihydroindeno[5,4-c]chromen-6(9H)-one 、 ciprofloxacin 在 NaOH 作用下， 以 甲醇 、 水 为溶剂， 以59.5%的产率得到[Cu(H2O)2(2-bromo-7-hydroxy-10,11-dihydroindeno[5,4-c]chromen-6(9H)-one(-1H))(ciprofloxacin(-1H))]*3H2O
  参考文献：
  名称：

  Antitubercular and fluorescence studies of copper(II) complexes with quinolone family member, ciprofloxacin

  摘要：

  Four new mixed-ligand complexes of Cu(II) with ciprofloxacin (Cip) and uninegative bidentate ligands have been synthesized and characterized. The structure of mixed-ligand complexes was investigated using spectroscopic method, physicochemical and elemental analyses. The fluorescence spectra of complexes show red shift, which may be due to the chelation by the ligands to the metal ion. It enhances ligand ability to accept electrons and decreases the electron transition energy. Antimycobacterial screening of ligand and its copper compound against Mycobacterium tuberculosis shows clear enhancement in the antitubercular activity upon copper complexation. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2011.03.032

文献信息

• Antitubercular and fluorescence studies of copper(II) complexes with quinolone family member, ciprofloxacin
  作者：G.J. Kharadi

  DOI：10.1016/j.saa.2011.03.032

  日期：2011.9

  Four new mixed-ligand complexes of Cu(II) with ciprofloxacin (Cip) and uninegative bidentate ligands have been synthesized and characterized. The structure of mixed-ligand complexes was investigated using spectroscopic method, physicochemical and elemental analyses. The fluorescence spectra of complexes show red shift, which may be due to the chelation by the ligands to the metal ion. It enhances ligand ability to accept electrons and decreases the electron transition energy. Antimycobacterial screening of ligand and its copper compound against Mycobacterium tuberculosis shows clear enhancement in the antitubercular activity upon copper complexation. (C) 2011 Elsevier B.V. All rights reserved.