(3aR,4S,7R,7aR)-2-[(1S)-1-phenylethyl]-3-{[(1S)-1-phenylethyl]amino}-2,3,3a,4,7,7a-hexahydro-1H-4,7-epoxyisoindole-1-one | 1314517-65-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: (3aR,4S,7R,7aR)-2-[(1S)-1-phenylethyl]-3-{[(1S)-1-phenylethyl]amino}-2,3,3a,4,7,7a-hexahydro-1H-4,7-epoxyisoindole-1-one
• CAS: 1314517-65-1
• 化学式: C₂₄H₂₆N₂O₂
• 分子量: 374.483
• InChiKey: UIFLOJUQUIUKNO-AXZYIJJZSA-N

反应信息

• 作为产物：
  描述：

  (3aSR,4SR,7RS,7aSR)-2-[(1S)-1-phenylethyl]-3-{[(1S)-1-phenylethyl]amino}-2,3,3a,4,7,7a-hexahydro-1H-4,7-epoxyisoindole-1-one 在 sodium tetrahydroborate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 6.0h， 以0.29 g的产率得到(3aR,4S,7R,7aR)-2-[(1S)-1-phenylethyl]-3-{[(1S)-1-phenylethyl]amino}-2,3,3a,4,7,7a-hexahydro-1H-4,7-epoxyisoindole-1-one
  参考文献：
  名称：

  Characteristic features of reduction with i-Bu2AlH of products of ring opening with (−)-α-methylbenzylamine of (3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-4,7-epoxy-2-benzofuran-1,3-dione

  摘要：

  A special procedure of synthesis was developed for amidoaminals of atypical topology through a reduction with i-Bu2AlH of primary products of thermodynamical opening of (3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-4,7-epoxy-2-benzofuran-1,3-dione at treating with (-)-alpha-methylbenzylamine. Characteristic spectral criteria are described for assignment of diastereomeric compounds; possible routes of reaction stages are considered.

  DOI：

  10.1134/s1070428011050101