1-(4-hydroxyphenyl)ethanamine hydrochloride | 860767-47-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1-(4-hydroxyphenyl)ethanamine hydrochloride
• 英文别名: (+/-)-4-(1-amino-ethyl)-phenol; hydrochloride；(+/-)-4-(1-Amino-aethyl)-phenol; Hydrochlorid；4-(1-Aminoethyl)phenol hydrochloride；4-(1-aminoethyl)phenol;hydrochloride
• CAS: 860767-47-1
• 化学式: C₈H₁₁NO*ClH
• 分子量: 173.642
• InChiKey: HNDFWZASJWHBCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.83
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.2
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为产物：
  描述：

  4-羟基苯乙酮肟 在 氨 、 sodium 作用下， 以 甲醇 为溶剂， 以75%的产率得到1-(4-hydroxyphenyl)ethanamine hydrochloride
  参考文献：
  名称：

  从烷基芳基酮和芳族醛合成功能取代的苄胺中不同还原体系的比较

  摘要：

  研究了功能性取代的苄胺的不同合成方法：烷基芳基酮的还原胺化和芳族醛肟的还原。最有效的方法用于制备一系列先前未知的羟基，烷氧基和卤素取代的苄胺。

  DOI：

  10.1134/s1070428010070110

文献信息

• 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH
  申请人：VESTAS WIND SYSTEMS A/S

  公开号：US20140235620A1

  公开（公告）日：2014-08-21

  The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 -R 6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

  该发明涉及公式（I）的化合物或其药用盐，其中R1-R6在此处定义。该发明还涉及含有公式（I）化合物的组合物，以及利用这些化合物抑制具有新型活性的突变IDH蛋白。该发明还涉及利用公式（I）的化合物治疗与这些突变IDH蛋白相关的疾病或紊乱，包括但不限于细胞增殖紊乱，如癌症。
• [EN] 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH<br/>[FR] 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES COMME INHIBITEURS D'IDH MUTANTE
  申请人：NOVARTIS AG

  公开号：WO2013046136A1

  公开（公告）日：2013-04-04

  The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formual (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

  该发明涉及公式(I)的化合物或其药学上可接受的盐，其中R1-R6在此处被定义。该发明还涉及含有公式(I)化合物的组合物，以及利用这些化合物抑制具有新型活性的突变IDH蛋白。该发明还涉及利用公式(I)的化合物治疗与这些突变IDH蛋白相关的疾病或紊乱，包括但不限于细胞增殖紊乱，如癌症。
• [EN] FUNGICIDAL PYRIMIDINE COMPOUNDS<br/>[FR] COMPOSÉS DE PYRIMIDINE FONGICIDES
  申请人：BASF SE

  公开号：WO2013113788A1

  公开（公告）日：2013-08-08

  The present invention relates to fungicidal pyrimidine compounds I, to their use and to methods for combating phytopathogenic fungi. The present invention also relates to seeds treated with at least one such compound. Furthermore the invention relates to processes for preparing compounds of formula I.

  本发明涉及杀真菌嘧啶化合物I，其用途以及用于防治植物病原真菌的方法。本发明还涉及至少一种受此类化合物处理的种子。此外，本发明还涉及制备式I化合物的方法。
• Modified protein adhesives and lignocellulosic composites made from the adhesives
  申请人：State of Oregon Acting By and Through the Oregon State

  公开号：US20040037906A1

  公开（公告）日：2004-02-26

  An adhesive composition made by reacting a soy protein with at least one compound under conditions sufficient for introducing additional phenolic hydroxyl functional groups, amine functional groups, and/or thiol functional groups into the soy protein structure.

  将大豆蛋白与至少一种化合物在足以向大豆蛋白结构中引入额外的酚羟基官能团、胺官能团和/或硫醇官能团的条件下进行反应而制成的粘合剂组合物。
• HAIR TREATMENT COMPOSITIONS INCORPORATING HAIR SUBSTANTIVE POLYMERS
  申请人：Unilever PLC

  公开号：EP2056788A1

  公开（公告）日：2009-05-13