8-(4-methoxy-benzyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione | 109339-90-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 8-(4-methoxy-benzyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
• 英文别名: 8-(4-Methoxy-benzyl)-1,3-dimethyl-3,7-dihydro-purin-2,6-dion；8-[(4-methoxyphenyl)methyl]-1,3-dimethyl-7H-purine-2,6-dione
• CAS: 109339-90-4
• 化学式: C₁₅H₁₆N₄O₃
• 分子量: 300.317
• InChiKey: OKAOCLOPJXFQQP-UHFFFAOYSA-N

物化性质

• 熔点：
  276.7-277.5 °C
• 沸点：
  584.3±60.0 °C(Predicted)
• 密度：
  1.326±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  78.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF
  申请人：Board of Regents, The University of Texas System

  公开号：US20220202821A1

  公开（公告）日：2022-06-30

  The present disclosure provides methods of inhibiting PARG in cancer cells, including methods comprising administering a PARG inhibitor that modulates position Tyr795 in PARG. Also provided herein are methods of treating and/or preventing cancer comprising administering a PARG inhibitor. In some embodiments, the PARG inhibitors are of the formula: wherein the variables are defined herein.
• [EN] SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS DE PARG À PETITES MOLÉCULES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV TEXAS

  公开号：WO2020205646A2

  公开（公告）日：2020-10-08

  The present disclosure provides methods of inhibiting PARG in cancer cells, including methods comprising administering a PARG inhibitor that modulates position Tyr795 in PARG. Also provided herein are methods of treating and/or preventing cancer comprising administering a PARG inhibitor. In some embodiments, the PARG inhibitors are of the formula: wherein the variables are defined herein.