9-(Benzoyloximino)-xanthen | 18791-24-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 9-(Benzoyloximino)-xanthen
• 英文别名: 9H-Xanthen-9-one, O-benzoyloxime；(xanthen-9-ylideneamino) benzoate
• CAS: 18791-24-7
• 化学式: C₂₀H₁₃NO₃
• 分子量: 315.328
• InChiKey: MNBSGYYGPFEBNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.26
• 重原子数：
  24.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.8
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  占吨酮 在 盐酸羟胺 、 sodium hydride 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 9-(Benzoyloximino)-xanthen
  参考文献：
  名称：

  Relationship Between Structure of Conjugated Oxime Esters and Their Ability to Cleave DNA

  摘要：

  The size and geometry of polycycles are critical to intercalation into DNA. This work involves the establishment of a new compound library that includes 35 O-benzoyl oxime esters with intercalators of five types. These conjugated compounds were synthesized by the condensation of substituted benzoyl chlorides (XC6H4COCl; X = H, Me, CN, F, and NO2) or naphthoyl chlorides with oximes of fluoren-9-one, 9,10-anthraquinone, xanthen-9-one, thioxanthen-9-one, and 9H-thioxanthen-9-one, 10,10-dioxide to give the corresponding esters in 80-99% yields. All of these compounds could cleave DNA when photolyzed by UV light. Of these conjugates, 9,10-anthraquinone-O-9-(4-fluorobenzoyl)oxime with a binding constant of 4.49 x 10(4) M-1 cleaved DNA most efficiently. Examination of the structure activity relationship supports a conclusion that two factors affect DNA-cleaving potency. These are (1) the planarity of the intercalating moiety, and (2) the size and substituents of the benzoyl ring. The DNA-cleaving ability followed the order 9,10-anthraquinone > fluoren-9-one >= xanthen-9-one similar to thioxanthen-9-one > 9H-thioxanthen-9-one 10,10-dioxide. The benzoyl-containing oxime ester conjugates were more active than the corresponding naphthoyl-containing conjugates. The potency that was associated with the different substituents on the benzoyl ring followed the order F > CN >= NO2 > Me similar to H.

  DOI：

  10.1021/bc400060h