6-(diethylamino)hexyl chloride | 74509-67-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 6-(diethylamino)hexyl chloride
• 英文别名: 6-diethylaminohexyl chloride；6-chlorohexyldiethylamine；diethyl-(6-chloro-hexyl)-amine；1-Chlor-6-diaethylamino-hexan；Diaethyl-(6-chlor-hexyl)-amin；6-chloro-N,N-diethylhexan-1-amine
• CAS: 74509-67-4
• 化学式: C₁₀H₂₂ClN
• 分子量: 191.744
• InChiKey: BWTNJIXPHGWEKV-UHFFFAOYSA-N

物化性质

• 沸点：
  118-120 °C(Press: 19 Torr)
• 密度：
  0.903±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-(diethylamino)hexyl chloride 在 乙醇 、 potassium iodide 作用下， 生成 (6-diethylamino-hexyl)-propyl-carbamic acid ethyl ester
  参考文献：
  名称：

  Wadia et al., Journal Of Scientific and Industrial Research, 1958, vol. 17B, p. 11,20

  摘要：

  DOI：
• 作为产物：
  描述：

  6-(二乙基氨基)-1-己醇 在 氯化亚砜 、 苯 作用下， 生成 6-(diethylamino)hexyl chloride
  参考文献：
  名称：

  Edwards; Stenlake, Journal of Pharmacy and Pharmacology, 1955, vol. 7, p. 852,859

  摘要：

  DOI：

文献信息

• Preparation of 7-aminoquinolines as candidate antiparasitic agents
  作者：Anica Markovac、Geng-Shuen Wu、Maurice P. Lamontagne、Peter Blumbergs、Ao Meng-Sheng

  DOI：10.1002/jhet.5570190424

  日期：1982.7

  A series of ten 7-quinolinediamines were prepared and evaluated for potential antiparasitic activity against P. berghei, P. cynomolgi, L. donovani and T. rhodesiense. Compounds 1d and 8 showed activity being slightly effective against L. donovani in hamsters.

  制备了一系列十种7-喹啉二胺，并评估了其对伯氏疟原虫，食蟹猴，杜氏罗非鱼 和罗氏疟原虫的潜在抗寄生虫活性。化合物1d和8显示出对仓鼠中的L. donovani稍有活性的活性。
• Neuromuscular Blocking Agents
  作者：D Edwards、J J Lewis、J B Stenlake、M S Zoha

  DOI：10.1111/j.2042-7158.1958.tb10389.x

  日期：2011.4.12

  The preparation of two further NSN-tris-ethonium compounds, 9-ethyl-9-thioniaheptadecylenebis(triethylammonium) triiodide (dioctasulphonium triethiodide; DOSE) and 11-ethyl-11-thioniaheneicosylenebis(triethylammonium) triiodide (didecasulphonium triethiodide; DDSE) is described. The bis-quaternary compound 7-dioxothiatridecylenebis(triethylammonium iodide), and the NNN-tris-quaternary compounds 7:7-diethyl-7-azoniatridecylenebis (triethylammonium) triiodide (dihexazonium triethiodide; DHAE), 9:9-diethyl-9-azoniaheptadecylenebis(triethylammonium triiodide (dioctazonium triethiodide; DOAE) and 11:11-diethyl-11-azoniahenicosylenebis(triethylammonium) triiodide (didecazonium triethiodide; DDAE) have also been synthesised. All the compounds possess neuromuscular blocking activity in the gastrocnemius muscle-sciatic nerve preparation of the cat, the phrenic nerve-diaphragm preparation of the rat and kitten and as measured by the rabbit head drop and mouse paralysis methods. Dihexazonium triethiodide and the sulphone 7-dioxathiatridecylenebis(triethylammonium iodide) (dihexone) show tubocurarine-like activity; dioctasulphonium triethiodide and dioctazonium triethiodide were predominantly tubocurarine-like but had some transitional properties, whilst didecasulphonium triethiodide and didecazonium triethiodide resembled decamethonium. Dihexazonium triethiodide was about equipotent with tubocurarine on the cat. Marked species variations in potency were observed. Theoretical implications are discussed.

  摘要：本文描述了两种新的NSN-三乙醇铵化合物的制备方法，分别为9-乙基-9-硫氮庚二烯双(三乙醇铵)三碘化物（二辛磺酸三乙硫碘酸盐；DOSE）和11-乙基-11-硫氮十二烯双(三乙醇铵)三碘化物（二十二磺酸三乙硫碘酸盐；DDSE）。还合成了双季铵化合物7-二氧代硫氮十三烯双(三乙醇铵碘化物)，以及NNN-三季铵化合物7:7-二乙基-7-氮杂硫氮十三烯双(三乙醇铵)三碘化物（二己杂铵三乙硫碘酸盐；DHAE）、9:9-二乙基-9-氮杂硫氮庚二烯双(三乙醇铵)三碘化物（二辛杂铵三乙硫碘酸盐；DOAE）和11:11-二乙基-11-氮杂硫氮十二烯双(三乙醇铵)三碘化物（二十二杂铵三乙硫碘酸盐；DDAE）。所有化合物在猫的腓肠肌-坐骨神经制备、大鼠和小猫的膈神经-膈肌制备，以及通过兔头下降和小鼠麻痹方法测量时均具有神经肌肉阻滞活性。二己杂铵三乙硫碘酸盐和7-二氧代硫氮十三烯双(三乙醇铵碘化物)（二己酮）表现出肌松药物样的活性；二辛磺酸三乙硫碘酸盐和二辛杂铵三乙硫碘酸盐主要表现出肌松药物样的特性，但也具有一些过渡性质，而二十二磺酸三乙硫碘酸盐和二十二杂铵三乙硫碘酸盐类似于十甲铵。在猫中，二己杂铵三乙硫碘酸盐的效力与肉豆蔻碱大致相同。观察到显著的物种差异。讨论了理论意义。
• Compositions providing improved functionalization of terminal anions and processes for improved functionalization of terminal anions
  申请人：——

  公开号：US20020010082A1

  公开（公告）日：2002-01-24

  Compositions including one or more anionic polymerization initiators and one or more additives for improving functionalizing efficiency of living polymer anions are disclosed. The present invention also provides compositions including one or more electrophiles and one or more additives for improving functionalizing efficiency of living polymer anions. Novel electrophiles and processes for improving polymer anion functionalization efficiencies are also disclosed.

  本发明公开了包括一种或多种阴离子聚合引发剂和一种或多种添加剂的组合物，用于提高活聚合物阴离子的官能化效率。本发明还提供了包括一种或多种亲电体和一种或多种添加剂的组合物，用于提高活聚合物阴离子的官能化效率。本发明还公开了用于提高聚合物阴离子官能化效率的新型亲电剂和工艺。
• Analogs of 8-[[6-(diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents
  作者：Maurice P. LaMontagne、Dinesh Dagli、M. Sami Khan、Peter Blumbergs

  DOI：10.1021/jm00183a004

  日期：1980.9

  8-[[6-(Diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline (I) has been shown to be highly effective against Leishmania donovani in hamsters, being approximately 475 times as active as the standard meglumine antimoniate. Several nuclear and side-chain analogues of I have been prepared in an attempt to further enhance the antileishmanial activity of this class of compounds. The compounds were tested against L. donovani in the golden hamster. Although several analogues had meglumine antimoniate indexes in excess of 300, none was superior to the model compound.
• 79. Antiplasmodial action and chemical constitution. Part VI. Compounds related to lepidylamine
  作者：Thomas S. Work

  DOI：10.1039/jr9420000426

  日期：——