N,N-dimethyl-[(3’,7’,9’,9’-tetramethyl)tricyclo[3.3.1.0^3,7]non-1-yl]amine | 1404321-61-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-dimethyl-[(3’,7’,9’,9’-tetramethyl)tricyclo[3.3.1.0^3,7]non-1-yl]amine
• 英文别名: N,N,3,7,9,9-hexamethyltricyclo[3.3.1.03,7]nonan-1-amine
• CAS: 1404321-61-4
• 化学式: C₁₅H₂₇N
• 分子量: 221.386
• InChiKey: BCXGXPCLFPQFLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  L-酒石酸 、 N,N-dimethyl-[(3’,7’,9’,9’-tetramethyl)tricyclo[3.3.1.0^3,7]non-1-yl]amine 以 甲醇 为溶剂， 以0.27 g的产率得到N,N-dimethyl-[(3’,7’,9’,9’-tetramethyl)tricyclo[3.3.1.0^3,7]non-1-yl]amine (2R,3R)-tartrate
  参考文献：
  名称：

  Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds

  摘要：

  The synthesis of several 2,2-dialkyladamantyl-1-amines through the combination of a Ritter reaction with a Wagner-Meerwein rearrangement from noradamantane alcohols is reported. Several of the novel amines displayed low micromolar activities against several H1N1 influenza virus strains, including the amantadine-resistant A/PuertoRico/8/34 strain. Most of the compounds did not show cytotoxicity for MDCK cells.

  DOI：

  10.1021/ml300279b
• 作为产物：
  描述：

  聚合甲醛 、 [(3’,7’,9’,9’-tetramethyl)tricyclo[3.3.1.0^3,7]non-1-yl]amine 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 甲醇 、 水 为溶剂， 反应 8.0h， 以96%的产率得到N,N-dimethyl-[(3’,7’,9’,9’-tetramethyl)tricyclo[3.3.1.0^3,7]non-1-yl]amine
  参考文献：
  名称：

  Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds

  摘要：

  The synthesis of several 2,2-dialkyladamantyl-1-amines through the combination of a Ritter reaction with a Wagner-Meerwein rearrangement from noradamantane alcohols is reported. Several of the novel amines displayed low micromolar activities against several H1N1 influenza virus strains, including the amantadine-resistant A/PuertoRico/8/34 strain. Most of the compounds did not show cytotoxicity for MDCK cells.

  DOI：

  10.1021/ml300279b

文献信息

• Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds
  作者：Eva Torres、Roser Fernández、Stéphanie Miquet、Mercè Font-Bardia、Evelien Vanderlinden、Lieve Naesens、Santiago Vázquez

  DOI：10.1021/ml300279b

  日期：2012.12.13

  The synthesis of several 2,2-dialkyladamantyl-1-amines through the combination of a Ritter reaction with a Wagner-Meerwein rearrangement from noradamantane alcohols is reported. Several of the novel amines displayed low micromolar activities against several H1N1 influenza virus strains, including the amantadine-resistant A/PuertoRico/8/34 strain. Most of the compounds did not show cytotoxicity for MDCK cells.