1-methyl-4-pentylpiperidine | 859297-41-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-methyl-4-pentylpiperidine
• 英文别名: 1-methyl-4-pentyl-piperidine；1-Methyl-4-pentyl-piperidin
• CAS: 859297-41-9
• 化学式: C₁₁H₂₃N
• 分子量: 169.31
• InChiKey: ZIYMXBJKSFWMFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-methyl-4-pentylpiperidine 在 四氟硼酸-二乙醚络合物 、 双氧水 、 溶剂黄146 作用下， 以 二氯甲烷 、 乙腈 、 水 为溶剂， 反应 1.5h， 以31%的产率得到5-(1-methylpiperidin-4-yl)pentan-2-one
  参考文献：
  名称：

  Remote Oxidation of Aliphatic C–H Bonds in Nitrogen-Containing Molecules

  摘要：

  Nitrogen heterocycles are ubiquitous in natural products and pharmaceuticals. Herein, we disclose a nitrogen complexation strategy that employs a strong Bronsted acid (HBF4) or an azaphilic Lewis acid (BF3) to enable remote, non-directed C(sp(3))-H oxidations of tertiary, secondary, and primary amine- and pyridine-containing molecules with tunable iron catalysts. Imides resist oxidation and promote remote functionalization.

  DOI：

  10.1021/jacs.5b10299
• 作为产物：
  描述：

  4-甲基吡啶 在 platinum(IV) oxide 、 正丁基锂 、 氢气 、 溶剂黄146 作用下， 以 四氢呋喃 、 正己烷 、 水 、 1,2-二氯乙烷 为溶剂， -78.0~20.0 ℃ 、413.7 kPa 条件下， 反应 50.5h， 生成 1-methyl-4-pentylpiperidine
  参考文献：
  名称：

  Remote Oxidation of Aliphatic C–H Bonds in Nitrogen-Containing Molecules

  摘要：

  Nitrogen heterocycles are ubiquitous in natural products and pharmaceuticals. Herein, we disclose a nitrogen complexation strategy that employs a strong Bronsted acid (HBF4) or an azaphilic Lewis acid (BF3) to enable remote, non-directed C(sp(3))-H oxidations of tertiary, secondary, and primary amine- and pyridine-containing molecules with tunable iron catalysts. Imides resist oxidation and promote remote functionalization.

  DOI：

  10.1021/jacs.5b10299

文献信息

• [EN] NOVEL COMPOUND, PREPARATION METHOD THEREOF, AND USE THEREOF<br/>[FR] NOUVEAU COMPOSÉ, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
  申请人：DAEGU GYEONGBUK MEDICAL INNOVATION FOUND

  公开号：WO2021145729A1

  公开（公告）日：2021-07-22

  The present invention relates to a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing the same as an active ingredient. The method for preparing a biomaterial to which a compound represented by formula 2 is coupled, of the present invention, allows the compound represented by formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient. In addition, the method can selectively functionalize tyrosine, and thus can be effectively used for tyrosine functionalization in a biomaterial.

  本发明涉及一种制备具有选择性功能化酪氨酸的生物材料的方法，具有选择性功能化酪氨酸的生物材料，以及含有该生物材料作为活性成分的药物组合物。本发明的一种制备生物材料的方法，其中将由式2表示的化合物偶联到生物材料，使得该化合物能够选择性地偶联到酪氨酸，且在生物材料中的产率较高，酪氨酸位于水溶液表面，使得其与酪氨酸以外的氨基酸不发生偶联，当只有一个酪氨酸存在时，不会出现异质混合物，同时保持生物材料的固有活性，因此该化合物可以有效地用作含有生物材料药物的药物组合物的活性成分。此外，该方法可以选择性功能化酪氨酸，因此可以有效地用于生物材料中的酪氨酸功能化。
• Pyridyl alkene and pyridyl alkine- acid amides as cytostatics and immuno-suppressives
  申请人：Biedermann Elfi

  公开号：US20070219197A1

  公开（公告）日：2007-09-20

  The present invention relates to new pyridine compounds, methods for their production, medicaments containing these compounds as well as their use, especially in the treatment of tumor conditions and/or as cytostatic agents or as immunosuppressive agents.

  本发明涉及新的吡啶化合物，其生产方法，含有这些化合物的药物以及它们的用途，特别是在肿瘤病情的治疗中和/或作为细胞毒剂或免疫抑制剂的用途。
• Pyridyl Alkene and Pyridyl Alkine-Acid Amides as Cytostatics and Immunosuppressives
  申请人：Biedermann Elfi

  公开号：US20070142377A1

  公开（公告）日：2007-06-21

  The invention relates to a new pyridyl alkene and pyridyl alkine acid amides according to the general formula (I) as well as methods for their production, medicaments containing these compounds as well as their medical use, especially in the treatment of tumors or for immunosuppression.

  该发明涉及一种新的吡啶基烯和吡啶基炔酸酰胺，其符合通式（I），以及其制备方法，含有这些化合物的药物以及它们在医学上的应用，特别是在肿瘤治疗或免疫抑制方面的应用。
• Piperazinyl-and piperidinyl-cyclohexanols
  申请人：Bristol-Myers Squibb Company

  公开号：EP0546583A1

  公开（公告）日：1993-06-16

  Novel piperazinyl- and piperidinyl-cyclohexanols of formula I are useful as anxiolytic agents and have other psychotropic properties.

  式 I 的新型哌嗪基和哌啶基环己醇可用作抗焦虑剂，并具有其他精神作用特性。
• Piperazinyl-and piperidinyl-cyclohexenes and cyclohexanes
  申请人：Bristol-Myers Squibb Company

  公开号：EP0560669A1

  公开（公告）日：1993-09-15

  Novel piperazinyl - and piperidinyl cyclohexenes which conform to the formula wherein R1 is H, C1-4 alkyl, C1-4 alkoxy, C1-4 trihaloalkyl or halogen ; X is an aryl or heteroaryl group ; n is 0,1,2, or 3; Cy is a 1-cyclohexene or cyclohexane residue, with the C=C of the cyclohexene group linked to X; Y is N or CH ; R2 and R3 are H or C1-4alkyl ; and Ar is a substituted or unsubstituted phenyl or a heteroaryl group are useful in the treatment of ischemia-induced disorders, eg., stroke, and for the treatment of psychosis.

  符合以下式子的新型哌嗪基和哌啶基环己烷 其中 R1 为 H、C1-4 烷基、C1-4 烷氧基、C1-4 三卤代烷基或卤素； X 是芳基或杂芳基； n 是 0、1、2 或 3； Cy 是 1-环己烯或环己烷残基，环己烯基团的 C=C 与 X 连接； Y 是 N 或 CH ； R2 和 R3 是 H 或 C1-4 烷基；以及 Ar 是取代或未取代的苯基或杂芳基。 可用于治疗缺血引起的疾病，如中风，以及治疗精神病。