N-(Hydroxymethyl)isopropylamine | 76733-33-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(Hydroxymethyl)isopropylamine
• 英文别名: (Propan-2-ylamino)methanol
• CAS: 76733-33-0
• 化学式: C₄H₁₁NO
• 分子量: 89.1374
• InChiKey: JMYPGIXUEBFAQW-UHFFFAOYSA-N

物化性质

• 沸点：
  121.4±23.0 °C(Predicted)
• 密度：
  0.880±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,4,6,8-tetraisopropyl-2,4,6,8-tetraazabicyclo<3.3.0>octane 以 氘代氯仿 为溶剂， 反应 60.0h， 生成 N,N'-二异丙基乙烷-1,2-二亚胺 、 N-(Hydroxymethyl)isopropylamine
  参考文献：
  名称：

  Polyazapolycyclics by condensation of aldehydes with amines. 3. Formation of 2,4,6,8-tetrabenzyl-2,4,6,8-tetraazabicyclo[3.3.0]octanes from formaldehyde, glyoxal, and benzylamines

  摘要：

  The condensation of formaldehyde, glyoxal, and benzylamine, in a stoichiometric ratio, leads to 2,4,6,8-tetrabenzyl-2,4,6,8-tetraazabicyclo[3.3.0]octane (1d) in methanol solvent with formic acid catalyst. Six phenyl-substituted derivatives of Id, as well as 2,4,6,8-tetraisopropyl-2,4,6,8-tetraazabicyclo[3.3.0]octane (1c), have been prepared in high yields by this synthetic method. Some of the chemical behavior of the new compounds is discussed.

  DOI：

  10.1021/jo00051a016

文献信息

• Polyazapolycyclics by condensation of aldehydes with amines. 3. Formation of 2,4,6,8-tetrabenzyl-2,4,6,8-tetraazabicyclo[3.3.0]octanes from formaldehyde, glyoxal, and benzylamines
  作者：Arnold T. Nielsen、Robin A. Nissan、Andrew P. Chafin、Richard D. Gilardi、Clifford F. George

  DOI：10.1021/jo00051a016

  日期：1992.12

  The condensation of formaldehyde, glyoxal, and benzylamine, in a stoichiometric ratio, leads to 2,4,6,8-tetrabenzyl-2,4,6,8-tetraazabicyclo[3.3.0]octane (1d) in methanol solvent with formic acid catalyst. Six phenyl-substituted derivatives of Id, as well as 2,4,6,8-tetraisopropyl-2,4,6,8-tetraazabicyclo[3.3.0]octane (1c), have been prepared in high yields by this synthetic method. Some of the chemical behavior of the new compounds is discussed.