2-diethylaminoquinazoline | 48149-11-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-diethylaminoquinazoline
• 英文别名: diethyl-quinazolin-2-yl-amine；2-Diethylaminochinazolin；N,N-diethylquinazolin-2-amine
• CAS: 48149-11-7
• 化学式: C₁₂H₁₅N₃
• 分子量: 201.271
• InChiKey: OFIVYNMLZWJPHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-异氰基苯甲腈 、 二乙胺 在 potassium carbonate 作用下， 反应 18.0h， 以100%的产率得到2-diethylaminoquinazoline
  参考文献：
  名称：

  New Access to 2,3-Disubstituted Quinolines through Cyclization of o-Alkynylisocyanobenzenes

  摘要：

  [GRAPHICS]o-Alkynylisocyanobenzenes underwent nucleophile-induced intramolecular cyclization to give 2,3-disubstituted quinoline derivatives in high yields. In addition to the oxygen and nitrogen nucleophiles such as methanol and diethylamine, the nucleophilic carbon of the enolate of malonate induced the cyclization effectively. Reaction of 1,4-di(trimethylsilylethynyl)-2,3-diisocyanobenzene with methanol afforded 2,9-dimethoxy-1,10-phenanthroline in good yield.

  DOI：

  10.1021/ol991133w

文献信息

• New Access to 2,3-Disubstituted Quinolines through Cyclization of <i>o</i>-Alkynylisocyanobenzenes
  作者：Michinori Suginome、Takeshi Fukuda、Yoshihiko Ito

  DOI：10.1021/ol991133w

  日期：1999.12.1

  [GRAPHICS]o-Alkynylisocyanobenzenes underwent nucleophile-induced intramolecular cyclization to give 2,3-disubstituted quinoline derivatives in high yields. In addition to the oxygen and nitrogen nucleophiles such as methanol and diethylamine, the nucleophilic carbon of the enolate of malonate induced the cyclization effectively. Reaction of 1,4-di(trimethylsilylethynyl)-2,3-diisocyanobenzene with methanol afforded 2,9-dimethoxy-1,10-phenanthroline in good yield.