4-氯-3-甲基-1-丁烯 | 10524-01-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 中文名称: 4-氯-3-甲基-1-丁烯
• 英文名称: methallyl chloride
• 英文别名: 4-Chlor-3-methyl-but-1-en；4-chloro-3-methyl-but-1-ene；4-Chloro-3-methyl-1-butene；4-chloro-3-methylbut-1-ene
• CAS: 10524-01-3
• 化学式: C₅H₉Cl
• 分子量: 104.579
• InChiKey: ZFXHRKNMXMGZNU-UHFFFAOYSA-N

物化性质

• 沸点：
  103.83°C (estimate)
• 密度：
  0.9000
• 保留指数：
  664;667

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2903299090

反应信息

• 作为反应物：
  描述：

  4-氯-3-甲基-1-丁烯 、 3-methyl-1-(phenylsulfonyl)but-2-ene 在 sodium hydroxide 、 四丁基溴化铵 作用下， 以 水 、 苯 为溶剂， 反应 2.0h， 以91%的产率得到2,6-dimethyl-4-(phenylsulphonyl)-1,5-heptadiene
  参考文献：
  名称：

  Jonczyk, Andrzej; Radwan-Pytlewski, Tadeusz, Gazzetta chimica Italiana, 1996, vol. 126, # 2, p. 111 - 119

  摘要：

  DOI：
• 作为产物：
  描述：

  天然橡胶 在 盐酸 作用下， 生成 4-氯-3-甲基-1-丁烯
  参考文献：
  名称：

  Surzur,J.-M.; Teissier,P., Bulletin de la Societe Chimique de France, 1970, p. 3060 - 3070

  摘要：

  DOI：

文献信息

• HOMOALLYL HALIDE COMPOSITION AND METHOD FOR STORING HOMOALLYL HALIDE
  申请人：KURARAY CO., LTD.

  公开号：US20180244593A1

  公开（公告）日：2018-08-30

  There is provided a composition containing one or more basic compounds selected from the group consisting of tertiary amines, nitrogen-containing heterocyclic aromatic compounds, alkali metal carbonate salts, alkaline earth metal carbonate salts and alkali metal hydrogencarbonate salts, and a homoallyl halide.

  提供一种含有从三级胺、含氮杂环芳香化合物、碱金属碳酸盐、碱土金属碳酸盐和碱金属氢碳酸盐组成的一种或多种基本化合物，以及同烯基卤代物的组合物。
• UNDERFILL ADHESIVES
  申请人：Woods John G.

  公开号：US20090018239A1

  公开（公告）日：2009-01-15

  In accordance with the present invention, it has now been found that glycidyl epoxy resins containing substitution on the epoxide ring can be used with conventional epoxy curing agents and fluxing agents to produce underfill adhesives that are suitable for use with silver-based alloys. Owing to the structural similarity of the new materials to conventional epoxy resins, physical and material properties of the invention formulations are altered little, if at all, relative to products currently in use, and so are highly compatible with existing processes.

  根据本发明，现已发现含有环氧环上取代基的环氧树脂可以与传统的环氧固化剂和流动剂一起使用，制造适用于银基合金的下填充粘合剂。由于新材料与传统环氧树脂的结构相似，因此与目前使用的产品相比，本发明配方的物理和材料性质几乎没有改变，因此与现有工艺高度兼容。
• Homoallyl halide composition and method for storing homoallyl halide
  申请人：KURARAY CO., LTD.

  公开号：US10618860B2

  公开（公告）日：2020-04-14

  There is provided a composition containing one or more basic compounds selected from the group consisting of tertiary amines, nitrogen-containing heterocyclic aromatic compounds, alkali metal carbonate salts, alkaline earth metal carbonate salts and alkali metal hydrogencarbonate salts, and a homoallyl halide.

  本发明提供了一种含有一种或多种碱性化合物的组合物，这些化合物选自由叔胺、含氮杂环芳香族化合物、碱金属碳酸盐、碱土金属碳酸盐和碱金属碳酸氢盐以及均烯丙基卤化物组成的组。
• Compounds selectively inhibiting gamma 9 delta 2 T lymphocytes
  申请人：INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

  公开号：US20040006131A1

  公开（公告）日：2004-01-08

  The invention concerns compounds of formula CH 3 —R 1 —(CH 2 ) 2 —R 2 wherein: R 1 is selected among a tertiary alcohol; a 1,2-diol; a halohydrine; an epoxide; an alkene; an aldehyde or an &agr;-hydroxyaldehyde; and R 2 is selected among a methylenediphosphonate; a difluoromethylenediphosphonate; or a monofluoromethylenediphosphonate. The invention also concerns the uses of said compounds as selective inhibitors of T&ggr;9&dgr;2 lymphocytes, and their uses, in particular for therapeutic purposes.

  本发明涉及式 CH 3 -R 1 -(CH 2 ) 2 -R 2 其中R 1 选自叔醇；1,2-二醇；卤代烃；环氧化物；烯烃；醛或&agr;-羟基醛；以及 R 2 选自亚甲基二磷酸酯、二氟甲基二磷酸酯或单氟甲基二磷酸酯。本发明还涉及上述化合物作为T&ggr;9&dgr;2淋巴细胞选择性抑制剂的用途及其使用，特别是用于治疗目的。
• Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816
  作者：J. H. Hutchinson、D. Riendeau、C. Brideau、C. Chan、D. Delorme、D. Denis、J. P. Falgueyret、R. Fortin、J. Guay

  DOI：10.1021/jm00071a008

  日期：1993.9

  Thiopyrano[2,3,4-c,d]indoles are a new class of 5-lipoxygenase (5-LO) inhibitors. SAR studies have demonstrated that the thiopyran ring, the 5-phenylpyridine substituent, and an acidic functional group on a four-carbon C-2 side chain are all required for optimal inhibitor potency. In contrast, the indolic nitrogen may be substituted with a variety of lipophilic groups. As a result of the SAR investigation, 44 (L-691,816; 5-[3-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5-dihydro-1H-thiopyrano[2,3,4-c,d]indol-2-yl]-2,2-dimethylpropyl]-1H-tetrazole) has been identified as a potent inhibitor of the 5-LO reaction both in vitro and in a range of in vivo models. Compound 44 inhibits 5-HPETE production by both rat and human 5-LO and LTB4 synthesis in human PMN leukocytes (IC50s 16,75, and 10 nM, respectively). The mechanism of inhibition of 5-LO activity by compound 44 appears to involve the formation of a reversible deadend complex with the enzyme and does not involve reduction of the nonheme iron of 5-LO. Compound 44 is highly selective for 5-LO when compared to the inhibition of human FLAP, porcine 12-LO, and also ram seminal vesicle cyclooxygenase. In addition, 44 is orally active in a rat pleurisy model (inhibition of LTB4, ED50 = 1.9 mg/kg; 8 h pretreatment) as well as in the hyperreactive rat model of antigen-induced dyspnea (ED50 = 0.1 mg/kg;2-h pretreatment). Excellent functional activity was also observed in both the conscious allergic monkey and sheep models of asthma. In the latter case, the functional activity observed correlated with the inhibition of urinary LTE4 excretion.