5-(alpha-Methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione | 858131-65-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5-(alpha-Methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione
• 英文别名: [(R)-[[(1S)-1-(4-bromophenyl)ethyl]amino]-(2,3-dioxo-1,4-dihydroquinoxalin-5-yl)methyl]phosphonic acid
• CAS: 858131-65-4
• 化学式: C₁₇H₁₇BrN₃O₅P
• 分子量: 454.2
• InChiKey: XXZGNAZRWCBSBK-HUTHGQBESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  128
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• COMPOSITIONS AND METHODS FOR TREATING BRAIN INJURY
  申请人：Poddar Ranjana

  公开号：US20210252026A1

  公开（公告）日：2021-08-19

  A method for treating a hyperhomocysteinemic subject having cerebral ischemic stroke generally includes administering to the hyperhomocysteinemic subject, following cerebral stroke, a composition that includes an inhibitor or an antagonist of a GluN2A-containing N-methyl-D-aspartate receptor (NMDAR) in an amount effective to ameliorate at least one symptom or clinical sign of cerebral stroke.