tert-butyl 4-(3,4,5-tris(octadecyloxy)benzoyl)piperazine-1-carboxylate | 1380432-97-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: tert-butyl 4-(3,4,5-tris(octadecyloxy)benzoyl)piperazine-1-carboxylate
• CAS: 1380432-97-2
• 化学式: C₇₀H₁₃₀N₂O₆
• 分子量: 1095.81
• InChiKey: OFUFPABCMIFIQQ-UHFFFAOYSA-N

物化性质

• 沸点：
  978.6±65.0 °C(Predicted)
• 密度：
  0.939±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  22.3
• 重原子数：
  78.0
• 可旋转键数：
  55.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  77.54
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  tert-butyl 4-(3,4,5-tris(octadecyloxy)benzoyl)piperazine-1-carboxylate 在 盐酸 作用下， 以 1,4-二氧六环 、 氯仿 、 乙酸乙酯 为溶剂， 反应 16.0h， 以81%的产率得到piperazin-1-yl(3,4,5-tris(octadecyloxy)phenyl)methanone hydrochloride
  参考文献：
  名称：

  Liquid-Phase RNA Synthesis by Using Alkyl-Chain-Soluble Support

  摘要：

  AbstractRecent progress in the RNA therapeutics has increased demand for the synthesis of large quantities of oligoribonucleotides. The assembly of RNA oligomers relies mainly on solid‐phase approaches. These allow rapid product purification and the ability to drive a target reaction to completion through the use of excess reagents. Despite the known advantages of solid‐phase synthesis, some issues in the process remain to be addressed, such as low and limited scale, reagent accessibility, and the use of a very large excess of reagents. Herein, we report a highly efficient and practical method of liquid‐phase synthesis of RNA oligomers by using alkyl‐chain‐soluble support. We demonstrate the utility of the liquid‐phase method through 21‐mer RNA synthesis on a gram scale.

  DOI：

  10.1002/chem.201300655
• 作为产物：
  描述：

  没食子酸甲酯 在 氯化亚砜 、 potassium carbonate 、 三乙胺 、 potassium hydroxide 作用下， 以 乙醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 33.0h， 生成 tert-butyl 4-(3,4,5-tris(octadecyloxy)benzoyl)piperazine-1-carboxylate
  参考文献：
  名称：

  Liquid-Phase RNA Synthesis by Using Alkyl-Chain-Soluble Support

  摘要：

  AbstractRecent progress in the RNA therapeutics has increased demand for the synthesis of large quantities of oligoribonucleotides. The assembly of RNA oligomers relies mainly on solid‐phase approaches. These allow rapid product purification and the ability to drive a target reaction to completion through the use of excess reagents. Despite the known advantages of solid‐phase synthesis, some issues in the process remain to be addressed, such as low and limited scale, reagent accessibility, and the use of a very large excess of reagents. Herein, we report a highly efficient and practical method of liquid‐phase synthesis of RNA oligomers by using alkyl‐chain‐soluble support. We demonstrate the utility of the liquid‐phase method through 21‐mer RNA synthesis on a gram scale.

  DOI：

  10.1002/chem.201300655

文献信息

• [EN] OLIGONUCLEOTIDES, REAGENTS AND PREPARATION THEREOF<br/>[FR] OLIGONUCLÉOTIDES, RÉACTIFS ET PRÉPARATION ASSOCIÉE
  申请人：[en]BIOGEN MA INC.

  公开号：WO2022103842A1

  公开（公告）日：2022-05-19

  The present disclosure describes novel reagents and processes for preparing oligonucleotides, which have two or more nucleotides. In one embodiment, the reagent is represented by Formula I' or B.