Ethyl 2-(8-fluoro-4-hydroxynaphthalen-2-yl)-1,3-thiazole-5-carboxylate | 1221565-49-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: Ethyl 2-(8-fluoro-4-hydroxynaphthalen-2-yl)-1,3-thiazole-5-carboxylate
• CAS: 1221565-49-6
• 化学式: C₁₆H₁₂FNO₃S
• 分子量: 317.341
• InChiKey: GQFGUJOZTOMIEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  87.7
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• FUSED-RING DERIVATIVE AND MEDICAL APPLICATION OF SAME
  申请人：Shimizu Kazuo

  公开号：US20110207935A1

  公开（公告）日：2011-08-25

  The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal plasma uric acid level and the like. The present invention relates to fused ring derivatives represented by the following formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of plasma uric acid level, prodrugs thereof, salts thereof or the like. In the formula (I), X 1 and X 2 represent CH or N; ring U represents aryl or heteroaryl; m represents integral number from 0 to 2; n represents integral number from 0 to 3; R 1 represents a hydroxy group, amino or C 1-6 alkyl; R 2 represents C 1-6 alkyl, C 1-6 alkoxy C 1-6 alkyl or the like.

  本发明提供了一种化合物，可用作预防或治疗与异常血浆尿酸水平等有关的疾病的药剂。本发明涉及以下式(I)所表示的融合环衍生物，具有黄嘌呤氧化酶抑制活性，并且可用作预防或治疗与血浆尿酸水平异常相关的疾病的药剂，其前药，盐或类似物。在式(I)中，X1和X2表示CH或N；环U表示芳基或杂环芳基；m表示从0到2的整数；n表示从0到3的整数；R1表示羟基，氨基或C1-6烷基；R2表示C1-6烷基，C1-6烷氧基C1-6烷基或类似物。
• US8263622B2
  申请人：——

  公开号：US8263622B2

  公开（公告）日：2012-09-11