2-(Furan-3-yl)-3-(6-methoxynaphthalen-2-yl)-8a-methylindolizin-1-one | 1221509-12-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(Furan-3-yl)-3-(6-methoxynaphthalen-2-yl)-8a-methylindolizin-1-one
• CAS: 1221509-12-1
• 化学式: C₂₄H₁₉NO₃
• 分子量: 369.42
• InChiKey: LMRJWZPCXMKVKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  42.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-呋喃硼酸 、 2-Iodo-3-(6-methoxynaphthalen-2-yl)-8a-methylindolizin-1-one 在 palladium 10% on activated carbon 、 sodium carbonate 作用下， 以 乙二醇二甲醚 、 水 为溶剂， 反应 5.0h， 以67%的产率得到2-(Furan-3-yl)-3-(6-methoxynaphthalen-2-yl)-8a-methylindolizin-1-one
  参考文献：
  名称：

  Diversity-Oriented Construction of Highly Substituted Indolizinones

  摘要：

  Rapid generation of small library of highly functionalized indolizonones was realized by exploiting three palladium-catalyzed cross-coupling reactions of 2-iodoindolizinones which in turn were readily accessed via sequential iodine-mediated cyclization/1,2-shift reactions of propargylic alcohols.

  DOI：

  10.1021/cc100015k

文献信息

• Diversity-Oriented Construction of Highly Substituted Indolizinones
  作者：Kyungsun Kim、Ikyon Kim

  DOI：10.1021/cc100015k

  日期：2010.5.10

  Rapid generation of small library of highly functionalized indolizonones was realized by exploiting three palladium-catalyzed cross-coupling reactions of 2-iodoindolizinones which in turn were readily accessed via sequential iodine-mediated cyclization/1,2-shift reactions of propargylic alcohols.