2-(2-propynyl)-3α,4,7,7α-tetrahydro-4,7-epoxy-1H-isoindole-1,3(2H)-dione | 272449-71-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(2-propynyl)-3α,4,7,7α-tetrahydro-4,7-epoxy-1H-isoindole-1,3(2H)-dione
• 英文别名: exo-N-(prop-2-ynyl)-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboximide；exo-N-prop-2-ynyl-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboximide；(3aS,4R,7S,7aR)-2-prop-2-ynyl-3a,4,7,7a-tetrahydro-4,7-epoxyisoindole-1,3-dione
• CAS: 272449-71-5
• 化学式: C₁₁H₉NO₃
• 分子量: 203.197
• InChiKey: GTMSPGUSFAMFDI-SPJNRGJMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-propynyl)-3α,4,7,7α-tetrahydro-4,7-epoxy-1H-isoindole-1,3(2H)-dione 以88%的产率得到1-(2-丙炔-1-基)-1H-吡咯-2,5-二酮
  参考文献：
  名称：

  N-烷基化马来酰亚胺的合成

  摘要：

  摘要 提出了 N-烷基化马来酰亚胺的两步合成。该方法允许使用广泛可用的起始材料并以高纯度和产率生产马来酰亚胺。马来酰亚胺前体对潜在的热固化和光固化聚合过程很感兴趣。

  DOI：

  10.1080/00397910008087165
• 作为产物：
  描述：

  exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride 、 炔丙胺 以 甲醇 为溶剂， 以81%的产率得到2-(2-propynyl)-3α,4,7,7α-tetrahydro-4,7-epoxy-1H-isoindole-1,3(2H)-dione
  参考文献：
  名称：

  通过点击化学合成定义良好的ω-氧杂降冰片烯基聚环氧乙烷大分子单体及其开环复分解聚合

  摘要：

  通过在乙炔基官能化的氧杂降冰片烯和ω-叠氮基聚环氧乙烷之间的Huisgen 1,3-偶极环加成反应，合成了分子量为500 g / mol至5000 g / mol的ω-氧杂降冰片烯基聚（环氧乙烷）单甲醚大分子单体。一甲醚。热分析表明，大分子单体的ω- exo-降冰片烯端基在130°C下通过逆Diels-Alder过程转化为马来酰亚胺基。在室温下，使用Grubbs催化剂在二氯甲烷中研究了这些大分子单体的开环复分解聚合（ROMP）。聚（oxanorbornene） -克-根据主链和接枝链的长度，得到具有1.04至1.17的多分散性和9900至57 800 g / mol的分子量的聚（环氧乙烷），导致梳状或刷状共聚物。

  DOI：

  10.1021/ma100779q

文献信息

• Combining Ring-Opening Metathesis Polymerization (ROMP) with Sharpless-Type “Click” Reactions: An Easy Method for the Preparation of Side Chain Functionalized Poly(oxynorbornenes)
  作者：Wolfgang H. Binder、Christian Kluger

  DOI：10.1021/ma0480087

  日期：2004.12.1

  ROMP yielding the final polymers; (b) the ROMP polymerization furnishing first poly(oxynorbornenes) bearing acetylenic and azido moieties and subsequently attaching the functional units by use of the “click” reactions onto the modified polymers. Both strategies show efficient functionalization behavior with a high tolerance of functional groups with respect to the functional units attached as demonstrated

  叠氮化物和乙炔之间的无尖锐的1,3-偶极环加成反应（“点击反应”）用于制备侧链内的功能性聚氧降冰片烯。应用了两种不同的策略将ROMP聚合物的制备方法与1,3-偶极环加成反应相结合：（a）通过1,3-偶极环加成反应将官能团（即疏水和氢键合单元）与7-带有乙炔的氧降冰片烯和随后的ROMP产生最终聚合物；（b）通过ROMP聚合反应，首先提供带有炔和叠氮基部分的聚（氧降冰片烯），然后通过“点击”反应将官能团连接到改性聚合物上。1 H和13 C NMR光谱学开辟了仅使用很少的原料制备多种官能化聚氧降冰片烯的可能性。
• Nanostructured Block-Random Copolymers with Tunable Magnetic Properties
  作者：Yongping Zha、Hitesh D. Thaker、Raghavendra R. Maddikeri、Samuel P. Gido、Mark T. Tuominen、Gregory N. Tew

  DOI：10.1021/ja305249b

  日期：2012.9.5

  It was recently shown that block copolymers (BCPs) produced room-temperature ferromagnetic materials (RTFMs) due to their nanoscopic ordering and the cylindrical phase yielded the highest coercivity. Here, a series of metal-containing block-random copolymers composed of an alkyl-functionalized homo block (C-16) and a random block of cobalt complex- (Co) and ferrocene-functionalized (Fe) units was synthesized via ring-opening metathesis polymerization. Taking advantage of the block-random architecture, the influence of dipolar interactions on the magnetic properties of these nanostructured BCP materials was studied by varying the molar ratio of the Co units to the Fe units, while maintaining the cylindrical phase-separated morphology. DC magnetic measurements, including magnetization versus field, zero-field-cooled, and field-cooled, as well as AC susceptibility measurements showed that the magnetic properties of the nanostructured BCP materials could be easily tuned by diluting the cobalt density with Fe units in the cylindrical domains. Decreasing the cobalt density weakened the dipolar interactions of the cobalt nanoparticles, leading to the transition from a room temperature ferromagnetic (RTF) to a superparamagnetic material. These results confirmed that dipolar interactions of the cobalt nanoparticles within the phase-separated domains were responsible for the RTF properties of the nanostructured BCP materials.
• Ferromagnetic block polymers and related methods
  申请人：Tew Gregory N.

  公开号：US20110064944A1

  公开（公告）日：2011-03-17

  Ferromagnetic multi-block copolymers of the sort which can be used to provide high-density, highly ordered thin films, composites and related articles.
• Synthesis on N-Alkylated Maleimides
  作者：Randell C. Clevenger、Kenneth D. Turnbull

  DOI：10.1080/00397910008087165

  日期：2000.4

  Abstract A two step synthesis of N-alkylated maleimides is presented. This method allows for the use of widely available starting materials and produces maleimides in high purity and yields. The maleimide precursors are of interest for potential thermo- and photo-setting polymerization processes.

  摘要 提出了 N-烷基化马来酰亚胺的两步合成。该方法允许使用广泛可用的起始材料并以高纯度和产率生产马来酰亚胺。马来酰亚胺前体对潜在的热固化和光固化聚合过程很感兴趣。
• Synthesis of Well-Defined ω-Oxanorbornenyl Poly(ethylene oxide) Macromonomers via Click Chemistry and Their Ring-Opening Metathesis Polymerization
  作者：D. Le、V. Montembault、J.-C. Soutif、M. Rutnakornpituk、Laurent Fontaine

  DOI：10.1021/ma100779q

  日期：2010.7.13

  maleimide group through a retro-Diels−Alder process at 130 °C. Ring-opening metathesis polymerization (ROMP) of these macromonomers was investigated using Grubbs’ catalyst in dichloromethane at room temperature. Poly(oxanorbornene)-g-poly(ethylene oxide)s were obtained with polydispersities between 1.04 and 1.17 and molecular weights between 9900 and 57 800 g/mol leading to comb or brush copolymers according

  通过在乙炔基官能化的氧杂降冰片烯和ω-叠氮基聚环氧乙烷之间的Huisgen 1,3-偶极环加成反应，合成了分子量为500 g / mol至5000 g / mol的ω-氧杂降冰片烯基聚（环氧乙烷）单甲醚大分子单体。一甲醚。热分析表明，大分子单体的ω- exo-降冰片烯端基在130°C下通过逆Diels-Alder过程转化为马来酰亚胺基。在室温下，使用Grubbs催化剂在二氯甲烷中研究了这些大分子单体的开环复分解聚合（ROMP）。聚（oxanorbornene） -克-根据主链和接枝链的长度，得到具有1.04至1.17的多分散性和9900至57 800 g / mol的分子量的聚（环氧乙烷），导致梳状或刷状共聚物。