3L7Trf9fcu | 878654-51-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 3L7Trf9fcu
• 英文别名: 2-cyclopentyl-N-(4-dipropylphosphorylphenyl)-9-ethylpurin-6-amine
• CAS: 878654-51-4
• 化学式: C₂₄H₃₄N₅OP
• 分子量: 439.5
• InChiKey: QWYGJEVWFGFNRP-UHFFFAOYSA-N

物化性质

• 沸点：
  588.0±60.0 °C(Predicted)
• 密度：
  1.25±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  72.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• MARKERS FOR SUSCEPTIBILITY TO AN INHIBITOR OF AN SRC-FAMILY KINASE
  申请人：Schaab Christoph

  公开号：US20140302172A1

  公开（公告）日：2014-10-09

  The present invention relates to a method for predicting the responsiveness of a mammalian tumor cell or cancer cell to an inhibitor of a kinase of the Src family, such as dasatinib, bosutinib, saracatinib or ponatinib. The present invention also provides for a method for predicting the responsiveness of an individual to an inhibitor of a kinase of the Src family, whereby the individual is suspected to suffer from cancer. These methods involve the evaluation of the status of integrin β4, wherein said status is indicative for the responsiveness to the inhibitor. Furthermore, a kit useful for carrying out the methods described herein as well as an oligo- or polynucleotide and/or antibodies capable of detecting the expression level of integrin β4 for predicting the responsiveness to the inhibitor are provided.
• US9328386B2
  申请人：——

  公开号：US9328386B2

  公开（公告）日：2016-05-03
• [EN] GDF15 IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS<br/>[FR] GDF15 DANS DES APPLICATIONS DE DIAGNOSTIC ET THÉRAPEUTIQUES
  申请人：UNIV EMORY

  公开号：WO2013012648A1

  公开（公告）日：2013-01-24

  The disclosure relates to compositions and methods for diagnostic and therapeutic purposes. In certain embodiments, the disclosure relates to pharmaceutical compositions and methods that interfere with GDF15 signaling or suppress GDF15 expression. In other embodiments, the disclosure relates to methods of determining therapeutic treatments after analyzing GDF15 expression.