1-octyloxy-3-isopropylamino-propan-2-ol | 1094635-85-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-octyloxy-3-isopropylamino-propan-2-ol
• 英文别名: 1-Octoxy-3-(propan-2-ylamino)propan-2-ol
• CAS: 1094635-85-4
• 化学式: C₁₄H₃₁NO₂
• mdl: MFCD11214615
• 分子量: 245.406
• InChiKey: SRVMNSHFBPIIFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• LIPID COMPOUNDS FOR SUPRESSION OF TUMORIGENESIS
  申请人：Svetlov Stanislav I.

  公开号：US20110177108A1

  公开（公告）日：2011-07-21

  The present invention provides compounds, or pharmaceutically acceptable salts or analogs thereof, which exhibit anti-tumor activity. The present invention also includes methods for inhibiting the growth of cancer cells by contacting an effective amount of a compound of the present invention with the cancer cells in vitro or in vivo.
• COMPOSITIONS AND METHODS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM TUMORS
  申请人：UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

  公开号：US20210130283A1

  公开（公告）日：2021-05-06

  Compounds, pharmaceutical compositions, and methods for treating cancer, in particular brain cancer, are provided, including amphiphilic fatty acid/alcohol ethers (AlPs) comprising endocannabinoid and FABP motifs covalently linked to a beta-adrenoreceptor antagonist motif in one molecule. The invention includes methods for inhibiting growth of brain cancer cells by contacting the compound(s) with brain cancer cells. The invention provides a method for treating both brain cancer and brain cancer metastases, and for suppression of regrowth of brain cancer cells after radiation, surgical treatment, or chemotherapy of brain cancer. The invention also comprises an optimized chemical synthesis of the AIP compounds and methods of using the compounds, alone or in combination with another agent, for suppressing the growth of brain cancer cells, and enhancing survival of normal CNS cells, or improving recuperation from radiation, surgical or chemotherapy.
• US8871983B2
  申请人：——

  公开号：US8871983B2

  公开（公告）日：2014-10-28
• [EN] LIPID COMPOUNDS FOR SUPRESSION OF TUMORIGENESIS<br/>[FR] COMPOSÉS LIPIDIQUES POUR SUPPRESSION DE TUMORIGÉNÈSE
  申请人：UNIV FLORIDA

  公开号：WO2010017550A2

  公开（公告）日：2010-02-11

  The present invention provides compounds, or pharmaceutically acceptable salts or analogs thereof, which exhibit anti-tumor activity. The present invention also includes methods for inhibiting the growth of cancer cells by contacting an effective amount of a compound of the present invention with the cancer cells in vitro or in vivo.
• [EN] LIPID COMPOUNDS FOR TREATMENT OF OBESITY, HYPERTENSION AND METABOLIC SYNDROME<br/>[FR] COMPOSÉS LIPIDIQUES POUR LE TRAITEMENT DE L'OBÉSITÉ, DE L'HYPERTENSION ET DU SYNDROME MÉTABOLIQUE
  申请人：UNIV FLORIDA

  公开号：WO2017031392A1

  公开（公告）日：2017-02-23

  The present invention provides compounds, or pharmaceutically acceptable salts or analogs thereof, for the treatment of obesity, hypertension and/or metabolic disorder.