4-[(1-{6-methanesulfonyl-5H,6H,7H,8H-pyridino[4,3-d]pyrimidine-2-yl}-1H-imidazol-4-yl)methyl]piperidine-1-carboxylic acid 1-methylcyclopropyl ester | 1182325-56-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 4-[(1-{6-methanesulfonyl-5H,6H,7H,8H-pyridino[4,3-d]pyrimidine-2-yl}-1H-imidazol-4-yl)methyl]piperidine-1-carboxylic acid 1-methylcyclopropyl ester
• 英文别名: 4-[(1-{6-methanesulfonyl-5H,6H,7H,8H-pyridino[4,3-d]pyrimidin-2-yl}-1H-imidazol-4-yl)methyl]piperidine-1-carboxylic acid 1-methylcyclopropyl ester；1-methylcyclopropyl 4-[(1-{6-methanesulfonyl-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-yl}-1H-imidazol-4-yl)methyl]piperidine-1-carboxylate；(1-methylcyclopropyl) 4-[[1-(6-methylsulfonyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl)imidazol-4-yl]methyl]piperidine-1-carboxylate
• CAS: 1182325-56-9
• 化学式: C₂₂H₃₀N₆O₄S
• 分子量: 474.584
• InChiKey: KYCHHRQBTWSMSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  119
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
  申请人：Azimioara Mihai

  公开号：US20110190263A1

  公开（公告）日：2011-08-04

  The invention provides compounds of Formula (I): pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.

  该发明提供了式（I）的化合物：包括这些化合物的药物组合物以及使用这些化合物治疗或预防与GPR119活性相关的疾病或障碍的方法。