6-n-butoxy-2-(3,5-di-tert-butyl-4-hydroxyphenyl)purine | 172154-62-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 6-n-butoxy-2-(3,5-di-tert-butyl-4-hydroxyphenyl)purine
• 英文别名: 4-(6-butoxy-7H-purin-2-yl)-2,6-ditert-butylphenol
• CAS: 172154-62-0
• 化学式: C₂₃H₃₂N₄O₂
• 分子量: 396.533
• InChiKey: SRFJZHYTZJIRHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  83.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Purine derivatives and suppressants for inflammatory diseases
  申请人：JAPAN ENERGY CORPORATION

  公开号：EP0675124A2

  公开（公告）日：1995-10-04

  Purine derivatives shown by general formula [I] or pharmacologically acceptable salts thereof. Suppressants for inflammatory diseases containing an effective ingredient of said purine derivative. (wherein, R represents one group selected from the groups composed of H atom, a straight chain alkyl group having 1-10 carbon atoms, a branched chain alkyl group having 3-10 carbon atoms, an alkyl group having 1-10 carbon atoms substituted with one carboxyl group, 4-carboxybenzyl group and phenethyl group). Above mentioned purine derivatives prevent the tissue damages due to mediators such as active oxygen and TXA2 in the initial stage of inflammation, and prevent the subsequent aggravation of inflammatory responses due to the adhesion of activated leukocytes to the cells in the lesion, and exhibit efficacy as anti-inflammatory drugs in all stages of inflammatory diseases caused by leukocytes.

  通式[I]所示的嘌呤衍生物或其药理上可接受的盐类。含有上述嘌呤衍生物有效成分的炎症性疾病抑制剂。 (其中，R 代表一个基团，选自 H 原子、1-10 个碳原子的直链烷基、3-10 个碳原子的支链烷基、1-10 个碳原子被一个羧基取代的烷基、4-羧基苄基和苯乙基组成的基团）。 上述嘌呤衍生物可防止炎症初期活性氧和 TXA2 等介质对组织造成的损害，并可防止活化的白细胞粘附在病变细胞上导致炎症反应加重，在白细胞引起的炎症性疾病的各个阶段都能发挥抗炎药物的功效。
• US5602140A
  申请人：——

  公开号：US5602140A

  公开（公告）日：1997-02-11