7a-phenyl-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione | 25860-43-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• 英文名称: 7a-phenyl-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione
• 英文别名: 7a-phenyl-6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1,3-dione
• CAS: 25860-43-9
• 化学式: C₁₂H₁₂N₂O₂
• 分子量: 216.239
• InChiKey: OPSLXYLNMLYTDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY
  申请人：GUILFORD PHARMACEUTICALS INC.

  公开号：EP1404325A2

  公开（公告）日：2004-04-07
• [EN] SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE<br/>[FR] PETITES MOLECULES DES PLUS UTILES DANS LE TRAITEMENT DE MALADIES INFLAMMATOIRES
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2001007052A1

  公开（公告）日：2001-02-01

  Novel compounds of formula (I) which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are: 2-(3,5-Dichlorophenyl)-7-(R*-phenyl-7a-(R*)-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione; 2-(3,5-Dichlorophenyl)-7a-(R*-methyl-7-(R*)-phenyl-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione; and, 7-(R*)-(4-Bromophenyl)-2-(3,5-dichlorophenyl)-7a-(R*)-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione.
• [EN] METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY<br/>[FR] PROCEDE DE TRAITEMENT D'ACCIDENTS NERVEUX ENTRAINES PAR UNE OPERATION
  申请人：GUILFORD PHARM INC

  公开号：WO2002096420A2

  公开（公告）日：2002-12-05

  The present invention relates generally to methods for treating or preventing nerve injury in a warm-blooded animal caused as a consequence of surgery by administering neurotrophic compounds described below. The invention relates more specifically to methods for treating or preventing nerve injury caused as a consequence of prostate surgery as well as erectile dysfunction.