N,N-dimethyl-4-(naphthalen-1-yl)-5-oxo-2,3,5,6,7,7a-hexahydro-1H-indole-1-carboxamide | 1428156-97-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N-dimethyl-4-(naphthalen-1-yl)-5-oxo-2,3,5,6,7,7a-hexahydro-1H-indole-1-carboxamide
• 英文别名: N,N-dimethyl-4-naphthalen-1-yl-5-oxo-3,6,7,7a-tetrahydro-2H-indole-1-carboxamide
• CAS: 1428156-97-1
• 化学式: C₂₁H₂₂N₂O₂
• 分子量: 334.418
• InChiKey: KAXPTRUNRBAHCG-UHFFFAOYSA-N

物化性质

• 沸点：
  571.8±50.0 °C(Predicted)
• 密度：
  1.25±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(but-3-yn-1-yl)cyclopropylamine 在 copper(l) iodide 、 chloro(1,5-cyclooctadiene)rhodium(I) dimer 、 四(三苯基膦)钯 、 sodium sulfate 、 三乙胺 、 三[3,4-双(三氟甲基)苯基]膦 作用下， 以 苯甲腈 、 N,N-二甲基甲酰胺 为溶剂， 130.0 ℃ 、101.33 kPa 条件下， 反应 174.0h， 生成 N,N-dimethyl-4-(naphthalen-1-yl)-5-oxo-2,3,5,6,7,7a-hexahydro-1H-indole-1-carboxamide
  参考文献：
  名称：

  Directing Group Enhanced Carbonylative Ring Expansions of Amino-Substituted Cyclopropanes: Rhodium-Catalyzed Multicomponent Synthesis of N-Heterobicyclic Enones

  摘要：

  Aminocyclopropanes equipped with suitable N-directing groups undergo efficient and regioselective Rh-catalyzed carbonylative C-C bond activation. Trapping of the resultant metallacycles with tethered alkynes provides an atom-economic entry to diverse N-heterobicyclic enones. These studies provide a blueprint for myriad N-heterocyclic methodologies.

  DOI：

  10.1021/ja401936c

文献信息

• Directed carbonylative (3+1+2) cycloadditions of amino-substituted cyclopropanes and alkynes: reaction development and increased efficiencies using a cationic rhodium system
  作者：Megan H. Shaw、William G. Whittingham、John F. Bower

  DOI：10.1016/j.tet.2015.08.052

  日期：2016.6

  Urea-directed carbonylative insertion of Rh(I)-catalysts into one of the two proximal C-C bonds of aminocyclopropanes generates rhodacyclopentanone intermediates. These are trapped by N-tethered alkynes to provide a (3+1+2) cycloaddition protocol that accesses N-heterobicyclic enones. Stoichiometric studies on a series of model rhodacyclopentanone complexes outline key structural features and provide a rationale for the efficacy of urea directing groups. A comprehensive evaluation of cycloaddition scope and a 'second generation' cationic Rh(I)-system, which provides enhanced yields and reaction rates for challenging substrates, are presented. (C) 2015 The Authors. Published by Elsevier Ltd.