Ethyl (+/-)-1,4-dihydro-5-isopropoxy-2-phenylsulphinyl-methyl-4-(2-trifluoromethylphenyl)-1,6-naphthyridine-3-carboxylate | 111839-71-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: Ethyl (+/-)-1,4-dihydro-5-isopropoxy-2-phenylsulphinyl-methyl-4-(2-trifluoromethylphenyl)-1,6-naphthyridine-3-carboxylate
• 英文别名: (+/-)-1,4-dihydro-5-isopropoxy-2-phenylsulphinylmethyl-4-(2-trifluoromethylphenyl)-1,6-naphthyridine-3-carboxylic acid ethyl ester；Ethyl (+/-)-1,4-dihydro-5-isopropoxy-2-phenylsulphinylmethyl-4-(2-trifluoromethylphenyl)-1,6-naphthyridine-3-carboxylate；ethyl 2-(benzenesulfinylmethyl)-5-propan-2-yloxy-4-[2-(trifluoromethyl)phenyl]-1,4-dihydro-1,6-naphthyridine-3-carboxylate
• CAS: 111839-71-5
• 化学式: C₂₈H₂₇F₃N₂O₄S
• 分子量: 544.595
• InChiKey: XLEXVWOMXQGBMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  96.7
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  (+/-)-1,4-dihydro-5-isopropoxy-2-phenylthiomethyl-4-(2-trifluoromethylphenyl)-1,6-naphthyridine-3-carboxylic acid ethyl ester 生成 Ethyl (+/-)-1,4-dihydro-5-isopropoxy-2-phenylsulphinyl-methyl-4-(2-trifluoromethylphenyl)-1,6-naphthyridine-3-carboxylate
  参考文献：
  名称：

  KLEINSCHROTH, JURGEN;MANNHARDT, KARL;HARTENSTEIN, JOHANNES;SATZINGER, GER+

  摘要：

  DOI：

文献信息

• 1,6-naphthyridine derivatives
  申请人：Goedecke Aktiengesellschaft

  公开号：US04751228A1

  公开（公告）日：1988-06-14

  The present invention provides 1,6-naphthyridine derivatives of formula ##STR1## wherein R.sup.1 is an unsubstituted or substituted aromatic or heteroaromatic ring or an unsubstituted or substituted condensed aromatic or heterocyclic ring system, R.sup.2 is a straight-chained or branched alkyl radical containing up to 4 carbon atoms, a benzyl radical or a straight-chained or branched, substituted or unsubstituted aminoalkyl radical containing up to 8 carbon atoms, R.sup.3 is a hydrogen atom, a straight-chained or branched alkyl radical or an alkoxycarbonyl radical, in each case containing up to 4 carbon atoms, R.sup.4 is a straight-chained or branched hydrocarbon radical containing up to 21 carbon atoms, which can also contain oxygen, sulphur, nitrogen or halogen atoms and is optionally substituted by carbocyclic or heterocyclic ring systems, or is an amino, cyano, formyl, halogenomethyl or dihalomethyl radical and R.sup.5 is an alkoxycarbonyl radical or an unsubstituted or substituted carboxamide radical with, in each case, up to 21 carbon atoms which can also contain oxygen, sulphur or nitrogen atoms and is optionally substituted by carbocyclic or heterocyclic ring systems or is a carboxyl or cyano group as well as the pharmaceutically acceptable salts thereof. The compounds are useful for blood vessel diseases. The present invention also provides processes for the preparation of these 1,6-naphthyridine derivatives, pharmaceutical compositions containing them, and methods for using them.

  本发明提供了公式##STR1##中的1,6-萘啉衍生物，其中R.sup.1是未取代或取代的芳香或杂环芳香环，或未取代或取代的紧凑芳香或杂环环系统，R.sup.2是含有最多4个碳原子的直链或支链烷基基团，苯甲基基团或含有最多8个碳原子的直链或支链，取代或未取代的氨基烷基基团，R.sup.3是氢原子，直链或支链烷基基团或烷氧羰基基团，每种情况下含有最多4个碳原子，R.sup.4是含有最多21个碳原子的直链或支链烃基基团，也可以含有氧、硫、氮或卤原子，并且可以选择地被碳环或杂环环系统取代，或者是氨基、氰基、甲醛基、卤代甲基或二卤代甲基基团，R.sup.5是烷氧羰基基团或含有最多21个碳原子的未取代或取代的羧酰胺基团，也可以含有氧、硫或氮原子，并且可以选择地被碳环或杂环环系统取代，或者是羧基或氰基以及其药学上可接受的盐。这些化合物对血管疾病有用。本发明还提供了制备这些1,6-萘啉衍生物的方法、含有它们的药物组合物以及使用它们的方法。
• KLEINSCHROTH, JURGEN;MANNHARDT, KARL;HARTENSTEIN, JOHANNES;SATZINGER, GER+
  作者：KLEINSCHROTH, JURGEN、MANNHARDT, KARL、HARTENSTEIN, JOHANNES、SATZINGER, GER+

  DOI：——

  日期：——
• 1,6-Naphthyridin-Derivate,Verfahren zu deren Herstellung und diese enthaltende Arzneimittel zur Behandlung von Gefässerkrankungen
  申请人：GÖDECKE AKTIENGESELLSCHAFT

  公开号：EP0234516B1

  公开（公告）日：1992-04-29