Chlorphosphan | 82614-82-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Chlorphosphan
• 英文别名: N,N'-diisopropylaminochlorophosphite；bis(diisopropylamino)chlorophosphine；Chlor[Bis(diisopropylamino)]phosphan；N-[chloro-(propan-2-ylamino)phosphanyl]propan-2-amine
• CAS: 82614-82-2
• 化学式: C₆H₁₆ClN₂P
• 分子量: 182.633
• InChiKey: OQXKITHQFKGADJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2,6-二甲氧基苯基)锂 、 Chlorphosphan 生成 N-[(2,6-dimethoxyphenyl)-(propan-2-ylamino)phosphanyl]propan-2-amine
  参考文献：
  名称：

  MCEWEN, W. E.;LAU, K. W., J. ORG. CHEM., 1982, 47, N 18, 3595-3596

  摘要：

  DOI：
• 作为产物：
  描述：

  二异丙胺 在 三氯化磷 作用下， 以 乙腈 为溶剂， 反应 8.75h， 生成 Chlorphosphan
  参考文献：
  名称：

  A sulfoximine-based inhibitor of human asparagine synthetase kills l-asparaginase-resistant leukemia cells

  摘要：

  An adenylated sulfoximine transition-state analogue 1, which inhibits human asparagine synthetase (hASNS) with nanomolar potency, has been reported to suppress the proliferation of an L-asparagine amidohydrolase (ASNase)-resistant MOLT-4 leukemia cell line (MOLT-4R) when L-asparagine is depleted in the medium. We now report the synthesis and biological activity of two new sulfoximine analogues of 1 that have been studied as part of systematic efforts to identify compounds with improved cell permeability and/or metabolic stability. One of these new analogues, an amino sulfoximine 5 having no net charge at cellular pH, is a better hASNS inhibitor (K*(I) = 8 nM) than 1 and suppresses proliferation of MOLT-4R cells at 10-fold lower concentration (IC50 = 0.1 mM). More importantly, and in contrast to the lead compound 1, the presence of sulfoximine 5 at concentrations above 0.25 mM causes the death of MOLT-4R cells even when ASNase is absent in the culture medium. The amino sulfoximine 5 exhibits different dose-response behavior when incubated with an ASNase-sensitive MOLT-4 cell line (MOLT-4S), supporting the hypothesis that sulfoximine 5 exerts its effect by inhibiting hASNS in the cell. Our work provides further evidence for the idea that hASNS represents a chemotherapeutic target for the treatment of leukemia, and perhaps other cancers, including those of the prostate. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.07.047

文献信息

• POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS
  申请人：TRANSLATE BIO, INC.

  公开号：US20200277446A1

  公开（公告）日：2020-09-03

  Disclosed are polymers comprising the moiety A, which is a moiety of formula I: and pharmaceutically acceptable salts thereof, wherein R, R 1 , R 2 , L, n1 and n2 are as defined herein. These polymers are useful for delivering nucleic acids to subject. These polymers and pharmaceutically acceptable compositions comprising such polymers and nucleic acids can be useful for treating various diseases, disorders and conditions.

  揭示了包含A基团的聚合物，该基团是化学式I的基团：及其药用可接受的盐，其中R、R1、R2、L、n1和n2如本文所定义。这些聚合物对于将核酸传递给受试者是有用的。这些聚合物和包含这些聚合物和核酸的药用可接受组合物可用于治疗各种疾病、疾病和症状。
• Synthesis of a double-phospholipid
  作者：F.M. Menger、X.Y. Chen

  DOI：10.1016/0040-4039(95)02163-9

  日期：1996.1

  A 72-membered macrocyclic phopholipid, which is a unimolecular version of the two-molecule unit spanning a membrane bilayer, was synthesized for the first time.

  首次合成了跨膜双层的两分子单元的单分子形式的72元大环磷脂。
• Poly(phosphoesters) for delivery of nucleic acids
  申请人：TRANSLATE BIO, INC.

  公开号：US11530298B2

  公开（公告）日：2022-12-20

  Disclosed are polymers comprising the moiety A, which is a moiety of formula I: and pharmaceutically acceptable salts thereof, wherein R, R 1 , R 2 , L, n1 and n2 are as defined herein. These polymers are useful for delivering nucleic acids to subject. These polymers and pharmaceutically acceptable compositions comprising such polymers and nucleic acids can be useful for treating various diseases, disorders and conditions.

  本发明公开了包含分子 A 的聚合物（分子 A 为式 I 的分子）及其药学上可接受的盐类，其中 R、R 1 , R 2 、L、n1 和 n2 如本文所定义。这些聚合物可用于向受试者提供核酸。这些聚合物以及包含此类聚合物和核酸的药学上可接受的组合物可用于治疗各种疾病、失调和病症。
• Turnbull, Mark M.; Wong, Edward H.; Gabe, Eric J., Inorganic Chemistry, 1986, vol. 25, # 18, p. 3189 - 3194
  作者：Turnbull, Mark M.、Wong, Edward H.、Gabe, Eric J.、Lee, Florence L.

  DOI：——

  日期：——
• Reau, Regis; Veneziani, Guilaine; Dahan, Francoise, Angewandte Chemie, 1992, vol. 104, # 4, p. 481 - 482
  作者：Reau, Regis、Veneziani, Guilaine、Dahan, Francoise、Bertrand, Guy

  DOI：——

  日期：——