benzyl 7-(4-hydroxy-3-methoxyphenyl)-5-methyl-4,7-dihydrotetrazolo [1,5-a] pyrimidine-6-carboxylate | 838814-50-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: benzyl 7-(4-hydroxy-3-methoxyphenyl)-5-methyl-4,7-dihydrotetrazolo [1,5-a] pyrimidine-6-carboxylate
• 英文别名: BHDPC；benzyl 7-(4-hydroxy-3-methoxyphenyl)-5-methyl-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate
• CAS: 838814-50-9
• 化学式: C₂₀H₁₉N₅O₄
• 分子量: 393.402
• InChiKey: BASOZMOVDGNDQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  5-氨基四氮唑 、 乙酰丙酮苄酯 、 香草醛 以 水 为溶剂， 以35%的产率得到benzyl 7-(4-hydroxy-3-methoxyphenyl)-5-methyl-4,7-dihydrotetrazolo [1,5-a] pyrimidine-6-carboxylate
  参考文献：
  名称：

  Synthesis of alkyl 5-aryl-7-methyl-1,5-dihydrotetrazolo-[1,5-a]pyrimidine-6-carboxylates

  摘要：

  Alkyl 5-aryl-7-methyl-1,5-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylates were obtained by melting acetoacetic acid esters with 5-aminotetrazole and aromatic aldehyde.

  DOI：

  10.1134/s1070428010050180

文献信息

• Method of treating and/or preventing neurodegenerative diseases
  申请人：University of Macau

  公开号：US20160113931A1

  公开（公告）日：2016-04-28

  The present disclosure provides a method of treating and/or preventing neurodegenerative diseases, such as Parkinson disease, Alzheimer disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis, comprising administrating a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof to a subject in need thereof.
• Synthesis of alkyl 5-aryl-7-methyl-1,5-dihydrotetrazolo-[1,5-a]pyrimidine-6-carboxylates
  作者：V. L. Gein、I. N. Vladimirov、O. V. Fedorova、A. A. Kurbatova、N. V. Nosova、I. V. Krylova、M. I. Vakhrin

  DOI：10.1134/s1070428010050180

  日期：2010.5

  Alkyl 5-aryl-7-methyl-1,5-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylates were obtained by melting acetoacetic acid esters with 5-aminotetrazole and aromatic aldehyde.