2-(2-methyl-1,3-benzothiazol-6-yl)-5-(pyridin-3-ylmethyl)-1,2,4,5,6,7-hexahydro-3H-pyrazolo[4,3-c]pyridin-3-one | 1331733-00-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: 2-(2-methyl-1,3-benzothiazol-6-yl)-5-(pyridin-3-ylmethyl)-1,2,4,5,6,7-hexahydro-3H-pyrazolo[4,3-c]pyridin-3-one
• 英文别名: 2-(2-Methyl-1,3-benzothiazol-6-yl)-5-(pyridin-3-ylmethyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-3-one
• CAS: 1331733-00-6
• 化学式: C₂₀H₁₉N₅OS
• 分子量: 377.47
• InChiKey: ZGUZDIDQNIPNSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  89.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] PYRAZOLO PIPERIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS<br/>[FR] DÉRIVÉS PYRAZOLO PIPÉRIDINE EN TANT QU'INHIBITEURS DE LA NADP OXYDASE
  申请人：GENKYOTEX SA

  公开号：WO2011101804A1

  公开（公告）日：2011-08-25

  The present invention is related to pyrazolo piperidine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及式（I）的吡唑吡啶衍生物，其制药组合物以及它们用于治疗和/或预防与尼古酰胺腺嘌呤二核苷酸磷酸氧化酶（NADPH氧化酶）相关的疾病或症状。
• Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
  申请人：GenKyoTex SA

  公开号：EP2361911A1

  公开（公告）日：2011-08-31

  The present invention is related to pyrazolo piperidine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及Formula (I)的吡唑哌啶衍生物、其药物组合物以及它们用于治疗和/或预防与烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NADPH氧化酶）相关的疾病或症状。
• Pyrazolo Piperidine Derivatives as NADPH Oxidase Inhibitors
  申请人：Page Patrick

  公开号：US20120316163A1

  公开（公告）日：2012-12-13

  The present invention is related to pyrazolo piperidine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及式(I)的吡唑啉哌啶衍生物、其制药组合物以及它们在治疗和/或预防与尼克酰胺腺嘌呤二核苷酸磷酸酰化酶（NADPH氧化酶）有关的疾病或症状方面的应用。
• PYRAZOLO PIPERIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS
  申请人：GenKyoTex SA

  公开号：EP2536723B1

  公开（公告）日：2013-12-11
• US8865758B2
  申请人：——

  公开号：US8865758B2

  公开（公告）日：2014-10-21