1,2,3,4-四氢苯并[ c ] -1,5-萘啶(5a)是通过涉及(±)-(Z)-1,10a-二氢吡咯并[1,2- b ]异喹啉-3,10(2 H,5 H)-二酮肟制得1,4-二氢苯并[ c ] -1,5-萘啶-2(3 H)-一,还原为5a。用5a观察到的拟胆碱活性促使其他类似物的合成和生物学评估。
Studies on pyrrolidinones. On the decarboxylation of pyroglutamic acids and N-acyl prolines in acidic media
作者:Rufine Akué-Gédu、Sahar Al Akoum Ebrik、Anne Witczak-Legrand、Dominique Fasseur、Samira El Ghammarti、Daniel Couturier、Bernard Decroix、Mohamed Othman、Marc Debacker、Benoı̂t Rigo
DOI:10.1016/s0040-4020(02)01183-3
日期:2002.11
During attempted Friedel–Crafts cyclization of some arylmethyl pyroglutamic acids or of N-phenacyl prolines, decomposition of the activated form of the acid have been observed, giving new heterocyclic systems. This general decarboxylation occurred when there are difficulties to realize a Friedel–Crafts cyclization and is explained by geometrical or electronic considerations.