Hydrin 1 | 122842-47-1

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: Hydrin 1
• 英文别名: (2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S)-2-[[(2S)-1-[(4R,7S,10S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
• CAS: 122842-47-1
• 化学式: C₅₇H₉₃N₂₁O₁₆S₂
• 分子量: 1392.6
• InChiKey: BJRAYGWQMPNTHC-CAOVDFMNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -9.3
• 重原子数：
  96
• 可旋转键数：
  33
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  687
• 氢给体数：
  20
• 氢受体数：
  22

文献信息

• TREATING DIABETES WITH OXYTOCIN OR OXYTOCIN ANALOGS
  申请人：Cai Dongsheng

  公开号：US20140066373A1

  公开（公告）日：2014-03-06

  Methods are provided of treating or preventing diabetes in a subject comprising administering to the subject an amount of oxytocin or an oxytocin analog. Methods are also provided of increasing insulin secretion in a subject comprising administering to the subject an amount of oxytocin or an oxytocin analog.
• [EN] USE OF OXYTOCIN OR OXYTOCIN ANALOGUES TO TREAT OBESITY AND DIABETES<br/>[FR] UTILISATION D'OXYTOCINE OU D'ANALOGUES D'OXYTOCINE POUR TRAITER L'OBÉSITÉ ET LE DIABÈTE
  申请人：EINSTEIN COLL MED

  公开号：WO2012161746A1

  公开（公告）日：2012-11-29

  Methods and compositions for treating obesity or an obesity comorbidity in a subject are provided, employing an inhibitor of synaptotagmin-4 or an amount of oxytocin or an analogue thereof. Methods and compositions for effecting weight gain in a subject are also provided employing synaptotagmin-4, or an analogue of synaptotagmin-4, or an oxytocin antagonist.