4β-Hydroxy-cholest-5-en | 20230-17-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 4β-Hydroxy-cholest-5-en
• 英文别名: (4S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-4-ol
• CAS: 20230-17-5
• 化学式: C₂₇H₄₆O
• 分子量: 386.662
• InChiKey: IYDDNBNPULHLAU-IWUBZGKGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4β-Hydroxy-cholest-5-en 在 氯化亚砜 、 乙醚 作用下， 生成 6β-Chlor-cholest-4-en
  参考文献：
  名称：

  Allylic Rearrangements. XLI. The Reaction of Thionyl Chloride with Steroid Allylic Alcohols¹

  摘要：

  DOI：

  10.1021/ja01550a047
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 4β-Hydroxy-cholest-5-en
  参考文献：
  名称：

  Jones et al., Journal of the Chemical Society, 1955, p. 2876,2883

  摘要：

  DOI：

文献信息

• Hydroxy-steroids. Part XI. The preparation and infrared spectra of vicinal cholestanediols
  作者：C. W. Davey、E. L. McGinnis、J. M. McKeown (née Chancellor)、G. D. Meakins、M. W. Pemberton、R. N. Young

  DOI：10.1039/j39680002674

  日期：——

  Twenty-eight vicinal cholestanediols (positions 1,2; 2,3; 3,4; 4,5; 5,6; 6,7; and 7,8) have been prepared by unambiguous routes starting from the corresponding olefins. The O–H stretching bands of dilute solutions of these diols and of seven reference compounds have been examined under high dispersion. Characteristic differences between ax,ax, ax,eq, and eq,eq compounds were observed. It was concluded

  已经通过从相应的烯烃开始的明确途径制备了二十八个邻位胆固醇二醇（1,2,2,3; 3,4; 4,5; 5,6; 6,7和7,8位）。这些二醇和七种参考化合物的稀溶液的O–H伸缩带已在高分散度下进行了检测。观察到ax，ax，ax，eq和eq，eq化合物之间的特性差异。结论是，不能通过游离和键合羟基的吸收之间的频率差来获得羟基之间的二面角的精确值。
• Steroids and Walden inversion. Part LIX. Reactions of some steroid α-hydroxyamines
  作者：C. W. Shoppee、P. Ram、S. K. Roy

  DOI：10.1039/j39660001023

  日期：——

  Reduction of 5-hydroxy-5α-cholestan-4-one oxime and 5-hydroxy-5α-cholestan-6-one oxime with sodium–ethanol and lithium aluminium hydride gives, inter alia, the 4β-, 6α-, and 6β-amino-5-hydroxy-5α-cholestanes, whose deamination is described and briefly discussed. Attempts to dehydrate these α-hydroxy-amines to the related allylic amines were unsuccessful, as also were attempted ammonolyses of 4β-chlorocholest-5-ene

  用钠-乙醇和氢化铝锂还原5-羟基-5α-胆甾烷-4-一肟和5-羟基-5α-胆甾烷-6-一肟，除其他外，得到4β-，6α-和6β-氨基-5-羟基-5α-胆甾烷，其脱氨基作用已描述并作了简要讨论。将这些α-羟基胺脱水为相关的烯丙基胺的尝试均未成功，也尝试了4β-chlorocholest-5-ene和6β-chlorocholest-4-ene的氨解反应。
• FUNCTIONALIZATION OF UNACTIVATED CARBON INVOLVING PHOTOCHEMICAL INTRAMOLECULAR REARRANGEMENT OF NITRO GROUP ATTACHED TO TETRAHEDRAL CARBON TO NITROSOOXY GROUP
  作者：Hiroshi Suginome、Kyohei Takakuwa、Kazuhiko Orito

  DOI：10.1246/cl.1982.1357

  日期：1982.9.5

  6β-nitrocholest-4-ene and 4β-nitrocholest-6-ene gave a mixture of (E)-19-hydroxyiminocholest-4-en-6β-ol and (E)-19-hydroxyiminocholest-5-en-4β-ol; this mixture arose in both cases from a photochemical nitro-nitrosooxy rearrangement followed by the Barton reaction. The structures of the products were established by their synthesis.

  6β-nitrocholest-4-ene 和 4β-nitrocholest-6-ene 的光解得到 (E)-19-hydroxyiminocholest-4-en-6β-ol 和 (E)-19-hydroxyiminocholest-5-en-的混合物4β-醇；在这两种情况下，这种混合物都来自光化学硝基 - 亚硝基氧基重排，然后是巴顿反应。产物的结构是通过它们的合成确定的。
• Nickel boride reductive cleavage of allylic trimethylsilyl ethers
  作者：D.N. Sarma、R.P. Sharma

  DOI：10.1016/s0040-4039(01)80820-0

  日期：——

  Nickel boride reductive cleavage of allylic trimethylsilyl ethers yielding alkenes is described.

  描述了烯丙基三甲基甲硅烷基醚的硼化镍还原裂解产生烯烃。
• Evaluation of Time-Resolved PM_2.5 Data in Urban/Suburban Areas of New Jersey
  作者：Nares Chuersuwan、Barbara J. Turpin、Charles Pietarinen

  DOI：10.1080/10473289.2000.10464214

  日期：2000.10

  Time-resolved data is needed for public notification of unhealthful air quality and to develop an understanding of atmospheric chemistry, including insights important to control strategies. In this research, continuous fine particulate matter (PM) mass concentrations were measured with tapered element oscillating microbalances (TEOMs) across New Jersey from July 1997 to June 1998. Data features indicating the influence of local sources and long-distance transport are examined, as well, as differences between 1-hr maxima and 24-hr average concentrations that might be relevant to acute health effects. Continuous mass concentrations were not significantly different from filter-collected gravimetric mass concentrations with 95% confidence intervals during any season. Annual mean PM2.5 concentrations from July 1997 to June 1998 were 17.3, 16.4, 14.1, and 15.3 mug/m(3) at Newark, Elizabeth, New Brunswick, and Camden, NJ, respectively. Monthly averaged 24- and 1-hr daily maximum PM2.5 concentrations suggest the existence of a high PM2.5 (May-October) and a low PM2.5 (November-April) season.PM2.5 magnitudes and temporal trends were very similar across the state during high PM, events. In fact, the between-site coefficients of determination (R-2) for daily PM2.5 measurements were 84-98% for June and July. Additionally, during the most pronounced PM2.5 episode, PM2.5 concentrations closely tracked the daily maximum 1-hr O-3 concentrations. These observations suggest the importance of transport and atmospheric chemistry (i.e., secondary formation) to PM2.5 episodes in New Jersey The influence of local sources was observed in diurnal concentration profiles and annual average between-site differences. Urban wintertime data illustrate that high 1-hr maximum PM2.5 concentrations can occur on low 24-hr PM2.5 days.