2,3-bis[(diethoxyphosphoryl)methyl]benzo[b]thiophene | 1269632-73-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 2,3-bis[(diethoxyphosphoryl)methyl]benzo[b]thiophene
• 英文别名: 2,3-Bis[[diethoxy(oxido)phosphaniumyl]methyl]-1-benzothiophene；2,3-bis[[diethoxy(oxido)phosphaniumyl]methyl]-1-benzothiophene
• CAS: 1269632-73-6
• 化学式: C₁₈H₂₈O₆P₂S
• 分子量: 434.43
• InChiKey: FNBGNJLIVMCUAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  27
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  111
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,3-双(溴甲基)-1-苯并噻吩 、 亚磷酸三乙酯 在 zinc dibromide 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以80%的产率得到2,3-bis[(diethoxyphosphoryl)methyl]benzo[b]thiophene
  参考文献：
  名称：

  Lewis Acid-Mediated Michaelis−Arbuzov Reaction at Room Temperature: A Facile Preparation of Arylmethyl/Heteroarylmethyl Phosphonates

  摘要：

  A facile preparation of arylmethyl and heteroarylmethyl phosphonate esters was achieved involving a Lewis acid mediated Michaelis-Arbuzov reaction at room temperature. Interaction of arylmethyl halides/alcohols with triethyl phosphite in the presence of Lewis acid at room temperature afforded phosphonate esters in good yields.

  DOI：

  10.1021/ol1029436

文献信息

• Lewis Acid-Mediated Michaelis−Arbuzov Reaction at Room Temperature: A Facile Preparation of Arylmethyl/Heteroarylmethyl Phosphonates
  作者：Ganesan Gobi Rajeshwaran、Meganathan Nandakumar、Radhakrishnan Sureshbabu、Arasambattu K Mohanakrishnan

  DOI：10.1021/ol1029436

  日期：2011.3.18

  A facile preparation of arylmethyl and heteroarylmethyl phosphonate esters was achieved involving a Lewis acid mediated Michaelis-Arbuzov reaction at room temperature. Interaction of arylmethyl halides/alcohols with triethyl phosphite in the presence of Lewis acid at room temperature afforded phosphonate esters in good yields.