8-Chloro-1-phenyl-1,2-dihydrochromeno[2,3-b]azepine-3,6-dione | 1522093-66-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 8-Chloro-1-phenyl-1,2-dihydrochromeno[2,3-b]azepine-3,6-dione
• 英文别名: 8-chloro-1-phenyl-2H-chromeno[2,3-b]azepine-3,6-dione
• CAS: 1522093-66-8
• 化学式: C₁₉H₁₂ClNO₃
• 分子量: 337.762
• InChiKey: KPMVHDUHOOUINE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-anilino-6-chloro-3-formylchromone 在 copper(l) iodide 、 碘 、 potassium carbonate 、 sodium iodide 作用下， 以 乙腈 为溶剂， 反应 15.0h， 生成 8-Chloro-1-phenyl-1,2-dihydrochromeno[2,3-b]azepine-3,6-dione
  参考文献：
  名称：

  Iodine/CuI-mediated alkyne–carbonyl metathesis reaction: synthesis of 1-aryl-1,2-dihydrochromeno[2,3-b]azepine-3,6-dione

  摘要：

  Iodine/cuprous iodide-mediated intramolecular alkyne carbonyl metathesis reaction has been developed using 2,-(N-aryl-N-propargyl)aminochromone-3-carbaldehyde as the substrate. It led to the synthesis of hitherto unreported chromeno[2,3-b]azepine-3,6-dione. The special features of this methodology are mild reaction conditions, 100% atom economy and use of inexpensive reagents. This is the first example of I-2/Cul-mediated alkyne carbonyl metathesis reaction. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.11.062

文献信息

• Iodine/CuI-mediated alkyne–carbonyl metathesis reaction: synthesis of 1-aryl-1,2-dihydrochromeno[2,3-b]azepine-3,6-dione
  作者：Sourav Maiti、Pritam Biswas、Jaydip Ghosh、Michael G.B. Drew、Chandrakanta Bandyopadhyay

  DOI：10.1016/j.tet.2013.11.062

  日期：2014.1

  Iodine/cuprous iodide-mediated intramolecular alkyne carbonyl metathesis reaction has been developed using 2,-(N-aryl-N-propargyl)aminochromone-3-carbaldehyde as the substrate. It led to the synthesis of hitherto unreported chromeno[2,3-b]azepine-3,6-dione. The special features of this methodology are mild reaction conditions, 100% atom economy and use of inexpensive reagents. This is the first example of I-2/Cul-mediated alkyne carbonyl metathesis reaction. (C) 2013 Elsevier Ltd. All rights reserved.