2-(1-benzothien-2-yl)-6-chloropyrazine | 868379-73-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 2-(1-benzothien-2-yl)-6-chloropyrazine
• 英文别名: 2-(1-Benzothiophen-2-yl)-6-chloropyrazine；2-(1-benzothiophen-2-yl)-6-chloropyrazine
• CAS: 868379-73-1
• 化学式: C₁₂H₇ClN₂S
• 分子量: 246.72
• InChiKey: IYKMYFQSVZSAPH-UHFFFAOYSA-N

物化性质

• 沸点：
  407.3±40.0 °C(Predicted)
• 密度：
  1.396±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯并噻吩-2-硼酸 、 2,6-二氯吡嗪 在 四(三苯基膦)钯 sodium carbonate 作用下， 以 水 、 甲苯 为溶剂， 反应 5.0h， 生成 2-(1-benzothien-2-yl)-6-chloropyrazine
  参考文献：
  名称：

  Polycyclic pyrazines as potassium ion channel modulators

  摘要：

  本发明提供了一类多环吡嗪，可作为钾离子通道调节剂。该发明的调节剂可用于治疗和诊断方法。

  公开号：

  US20050239800A1

文献信息

• POLYCYCLIC PYRAZINES AS POTASSIUM ION CHANNEL MODULATORS
  申请人：Icagen, Inc.

  公开号：EP1742935A1

  公开（公告）日：2007-01-17
• US7642354B2
  申请人：——

  公开号：US7642354B2

  公开（公告）日：2010-01-05
• [EN] POLYCYCLIC PYRAZINES AS POTASSIUM ION CHANNEL MODULATORS<br/>[FR] PYRAZINES POLYCYCLIQUES TENANT LIEU DE MODULATEURS DU CANAL IONIQUE DU POTASSIUM
  申请人：ICAGEN INC

  公开号：WO2005121126A1

  公开（公告）日：2005-12-22

  The present invention provides a genus of polycyclic pyrazines of formula I (I) that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods; wherein A and B are independently substituted or unsubstituted 5- or 6-membered heterocycloalkyl, or substituted or unsubstituted 5- or 6- membered heteroaryl, W1 is formula II (II); W2 is -CH=, -NH-, -N=, -S-, or -O-; Z1 is formula III (III) or formula IV (IV); Z2 is -CH=, -NH-, -N=, -S-, or -O-; Y is a bond, -CH=N-NH-, -NH-CH2-, or -NR5-; s and t are independently integers from 1 to 4; R1, R2A, R2B and R3 are independently or unsubstituted alkyle, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl,, substituted or unsubstituted 5- to 7-membered heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R5 is H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl,, substituted or unsubstituted 5- to 7-membered heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; wherein if s is greater than one, then each R1 is optionally different; wherein if t is greater than on, then each R3 is optionally different; wherein two R1 groups are optionally joined together with the atoms to which they are attached to form a substituted or unsubstituted ring; and wherein two R3 groups are optionally joined together with the atoms to which they are attached to form a susbtituted or unsubstituted ring.